Guidance on JAK inhibitor treatment for inborn errors of JAK-STAT signaling, 2026: International consensus statement on behalf of the European Society for Immunodeficiencies/European Society for Blood and Marrow Transplantation–Inborn Errors Working Party and ERN-RITA

Filiaciones

Olbrich P.:

Instituto de Biomedicina de Sevilla, Research Group “Inborn Errors of Immunity”, Pediatric Infectious Diseases, Rheumatology and Immunology Unit, IBiS/Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla, Red de Investigación Traslacional en Infectología Pediátrica RITIP, Seville, Spain

Departamento de Farmacología, Pediatría y Radiología, Facultad de Medicina, Universidad de Sevilla, Seville, Spain

Fischer M.:

Department of Allergology and Clinical Immunology, Children’s Hospital of Eastern Switzerland, Sankt Gallen, Switzerland

Department of Quantitative Biomedicine, Center for Human Immunology, University of Zurich, Zurich, Switzerland

Deyà-Martinez Á.:

Institut de Recerca Hospital Sant Joan de Déu, Universitat de Barcelona, Barcelona, Spain

Clinical Immunology Unit Hospital, Sant Joan de Déu–Hospital Clínic de Barcelona, Barcelona, Spain

Campos-Asensio C.:

Biblioteca Médica, Hospital Universitario de Getafe, Madrid, Spain

Neth O.:

Instituto de Biomedicina de Sevilla, Research Group “Inborn Errors of Immunity”, Pediatric Infectious Diseases, Rheumatology and Immunology Unit, IBiS/Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla, Red de Investigación Traslacional en Infectología Pediátrica RITIP, Seville, Spain

Departamento de Farmacología, Pediatría y Radiología, Facultad de Medicina, Universidad de Sevilla, Seville, Spain

Hadjadj J.:

Department of Internal Medicine, Sorbonne University, Assistance Publique Hôpitaux de Paris, Saint-Antoine Hospital, Paris, Ireland

Laboratory of Immunogenetics of Pediatric Autoimmune Diseases, Institut National de la Santé et de la Recherche Médicale (INSERM) UMR 1163, University Paris Cité, Institut Imagine, Paris, France

Forbes Satter L.R.:

Department of Pediatrics, Baylor College of Medicine, Texas Children’s Hospital, Tex, Houston, Ireland

Department of Pediatrics, Baylor College of Medicine, Immunology/Allergy/Retrovirology, Texas Children’s Hospital, Tex, Houston, Ireland

Leiding J.W.:

Department of Pediatrics, Division of Allergy and Immunology, Johns Hopkins University, Md, Baltimore, Ireland

Institute for Clinical and Translational Research and Cancer and Blood Disorders Institute, Johns Hopkins All Children’s Hospital, Fla, St Petersburg, Ireland

Torgerson T.R.:

Allen Institute for Immunology, Wash, Seattle, Ireland

Bakhtiar S.:

Division for Stem Cell Transplantation and Immunology, Department for Pediatrics, Goethe University Hospital Frankfurt, Frankfurt am Main, Germany

Baris S.:

Marmara University, Faculty of Medicine, Department of Pediatric Allergy and Immunology, Istanbul, Turkey

Istanbul Jeffrey Modell Diagnostic and Research Center for Primary Immunodeficiencies, Istanbul, Turkey

The Isil Berat Barlan Center for Translational Medicine, Istanbul, Turkey

Badolato R.:

Clinica Pediatrica dell’Università degli Studi di Brescia, ASST Spedali Civili, Brescia, Italy

Bloomfield M.:

Department of Immunology, Motol and Homolka University Hospital, 2nd Faculty of Medicine, Charles University, Prague, Czech Republic

Paediatric Department, Thomayer’s University Hospital, 1st Faculty of Medicine, Charles University, Prague, Czech Republic

Buddingh E.P.:

Willem-Alexander Children’s Hospital, Leiden University Medical Center, Leiden, Netherlands

Burroughs L.M.:

Clinical Research Division, Fred Hutchinson Cancer Center, Wash, Seattle, Ireland

Department of Pediatrics, University of Washington School of Medicine, Wash, Seattle, Ireland

Burns S.:

Institute of Immunity and Transplantation, University College London, London, United Kingdom

Cooper M.A.:

Department of Pediatrics, Division of Rheumatology and Immunology, Washington University School of Medicine, Mo, St Louis, Ireland

Department of Pathology and Immunology, Washington University School of Medicine, Mo, St Louis, Ireland

Crickx E.:

Service de médecine interne, Centre national de référence des cytopénies auto-immunes de l’adulte, Hôpital Henri Mondor, Fédération Hospitalo-Universitaire TRUE InnovaTive theRapy for immUne disorders, Assistance Publique Hôpitaux de Paris (AP-HP), Université Paris Est Créteil, Paris, France

Ehl S.:

Institute for Immunodeficiency, Center for Chronic Immunodeficiency, University Medical Center, Faculty of Medicine, University of Freiburg, Freiburg, Germany

Farmand S.:

Division of Pediatric Stem Cell Transplantation and Immunology, Department of Pediatric Hematology and Oncology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany

Freeman A.F.:

Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Md, Bethesda, Ireland

González-Granado L.I.:

Hospital Universitario 12 de Octubre, Spain, Madrid, Ireland

Research Institute Hospital 12 Octubre imas12, Spain, Madrid, Ireland

Departament of Pediatrics, Complutense University of Madrid, Spain, Madrid, Ireland

Hagin D.:

Allergy and Clinical Immunology Unit, Department of Medicine, Tel Aviv Sourasky Medical Center and Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel

Hanitsch L.G.:

Institute of Medical Immunology, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Berlin, Germany

Humboldt Universität zu Berlin and Berlin Institute of Health, Berlin Institute of Health (BIH) Center for Regenerative Therapies, Berlin, Germany

Hanzlikova J.:

Department of Immunology and Allergology, Faculty of Medicine and Faculty Hospital, Pilsen, Ireland

Hauck F.:

Division of Pediatric Hematology/Oncology, Immunology and Rheumatology, Department of Pediatrics, Dr. von Hauner Children’s Hospital, University Hospital, Ludwig-Maximilians-Universität München, Munich, Germany

Ivorra-Cortés J.:

Hospital Universitario y Politécnico La Fe, Valencia, Spain

Körholz J.:

Department of Pediatrics and University Center for Rare Diseases, Medizinische Fakultät Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany

Lankester A.C.:

Willem-Alexander Children’s Hospital, Leiden University Medical Center, Leiden, Netherlands

Department of Pediatrics, Willem-Alexander Children’s Hospital, Leiden University Medical Center, Leiden, Netherlands

Leahy T.R.:

Children’s Health Ireland, Crumlin, Dublin, Ireland

Meyts I.:

Department of Microbiology, Immunology and Transplantation, Laboratory for Inborn Errors of Immunity, Katholieke Universiteit (KU) Leuven, Belgium, Leuven, Ireland

Department of Pediatrics, University Hospitals Leuven, KU Leuven, Belgium, Leuven, Ireland

Milner J.D.:

Division of Allergy, Immunology and Rheumatology, Columbia University Medical Center, NewYork-Presbyterian Morgan Stanley Children’s Hospital, New York, NY, United States

Nademi Z.:

Children’s Hematopoietic Stem Cell Transplant Unit, Great North Children’s Hospital, Newcastle upon Tyne, United Kingdom

Pachlopnik-Schmid J.:

Division of Immunology, University Children’s Hospital and Children’s Research Center Zurich, Zurich, Switzerland

Faculty of Medicine, University of Zurich, Zurich, Switzerland

Pergent M.:

International Patient Organisation for Primary Immunodeficiencies (IPOPI), Brussels, Belgium

Prévot J.:

International Patient Organisation for Primary Immunodeficiencies (IPOPI), Brussels, Belgium

Rivière J.:

Infection and Immunity in Pediatric Patients Research Group, Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain

Pediatric Infectious Diseases and Immunodeficiencies Unit, Vall d’Hebron Barcelona Hospital Campus, Barcelona, Spain

Jeffrey Modell Diagnostic and Research Center for Primary Immunodeficiencies, Barcelona, Spain

Roxo-Junior P.:

Division of Immunology & Allergy, Dept.of Pediatrics, Ribeirão Preto Medical School, University of São Paulo, São Paulo, Brazil

Schütz C.:

Department of Pediatrics and University Center for Rare Diseases, Medizinische Fakultät Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany

Slatter M.A.:

Children’s Hematopoietic Stem Cell Transplant Unit, Great North Children’s Hospital, Newcastle upon Tyne, United Kingdom

Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, United Kingdom

Soler-Palacin P.:

Infection and Immunity in Pediatric Patients Research Group, Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain

Pediatric Infectious Diseases and Immunodeficiencies Unit, Vall d’Hebron Barcelona Hospital Campus, Barcelona, Spain

Jeffrey Modell Diagnostic and Research Center for Primary Immunodeficiencies, Barcelona, Spain

Warnatz K.:

Institute for Immunodeficiency, Center for Chronic Immunodeficiency, University Medical Center, Faculty of Medicine, University of Freiburg, Freiburg, Germany

Department of Immunology, University Hospital Zurich, Zurich, Switzerland

Vítovcová P.:

Department of Allergology and Immunology, University Hospital Pilsen, Pilsen, Czech Republic

Vaastert S.J.:

Department of Paediatric Rheumatology and Immunology, Wilhelmina Children’s Hospital, University Medical Center Utrecht and Utrecht University, Utrecht, Netherlands

Center for Translational Immunology, University Medical Center Utrecht, Utrecht, Netherlands

Neven B.:

Immuno-hematology and Rheumatology Unit, Necker Children’s Hospital, Assistance Publique-Hôpitaux de Paris, Université de Paris, INSERM UMR 1163, Institut Imagine, Paris, France

Albert M.H.:

Division of Pediatric Hematology/Oncology, Immunology and Rheumatology, Department of Pediatrics, Dr. von Hauner Children’s Hospital, University Hospital, Ludwig-Maximilians-Universität München, Munich, Germany

Speckmann C.:

Institute for Immunodeficiency, Center for Chronic Immunodeficiency, University Medical Center, Faculty of Medicine, University of Freiburg, Freiburg, Germany

Division of Pediatric Hematology and Oncology, Children’s Hospital, University Medical Center Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany