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  3. Analysis of the Influence of Sex in 507 Patients With Moderate-to-Severe Atopic Dermatitis: Spanish Atopic Dermatitis Registry (BIOBADATOP);

Analysis of the Influence of Sex in 507 Patients With Moderate-to-Severe Atopic Dermatitis: Spanish Atopic Dermatitis Registry (BIOBADATOP);

Fecha de publicación:

Autores de IIS La Fe

Participantes ajenos a IIS La Fe

  • Navarro-Bielsa A.
  • Gilaberte Y.
  • Carrascosa J.M.
  • Ruiz-Villaverde R.
  • Betlloch Mas I.
  • Espasandín-Arias M.
  • Lasheras-Pérez M.A.
  • González Quesada A.
  • de la Cueva Dobao P.
  • Chicharro P.
  • Pereyra Rodríguez J.J.
  • Herrera Acosta E.
  • Montero-Vilchez T.
  • Elosua-González M.
  • Curto-Barredo L.
  • Munera-Campos M.
  • Navarro-Triviño F.J.
  • Batalla A.
  • Castaño-González I.
  • Alonso J.
  • Arias-Santiago S.
  • Roustan Gullón G.
  • Bertolín-Colilla M.
  • Ruiz Carrascosa J.C.
  • Couselo-Rodríguez C.
  • Sanabria de la Torre R.
  • Rosell-Díaz A.
  • Giménez-Arnau A.M.
  • Martínez-Fernández S.
  • García-Doval I.
  • Descalzo-Gallego M.Á.
  • Silvestre Salvador J.F.

Grupos

Abstract

Introduction Atopic dermatitis (AD) is a common chronic inflammatory disease that presents differences in clinical expression according to sex. The aim of this study was to evaluate the influence of sex on disease severity, comorbidities, treatments, and adverse events in patients with moderate-to-severe AD included in the Spanish BIOBADATOP registry. Methods We conducted a prospective observational study using data from the BIOBADATOP registry from March 2020 to February 2025. Demographic variables, severity scales (EASI, DLQI, POEM, pruritus VAS), comorbidities, treatments, and adverse events were collected. Statistical analysis was performed using Chi-square, Student's t -test, and Mann–Whitney tests, considering statistical significance at P < .05. Results A total of 507 adult patients on systemic treatment were included (53.1% men, 46.9% women). Men showed greater disease severity according to EASI (21.7 vs 21.0) and higher serum IgE levels (1323 vs 638 KU/L). Women reported greater pruritus intensity and worse POEM scores. Anxiety (26% vs 13%) and depression (15% vs 5%) were more frequent among women. No differences were observed in family history or atopic comorbidities. Similarly, no relevant differences were found in treatments received, treatment duration, or clinical response at 3, 6, and 12 months. However, women showed a higher rate of GI adverse events (97/1000 vs 19/1000 patient-years). Conclusions Clinical and comorbidity differences according to sex exist in moderate-to-severe AD. Men show greater disease severity and higher IgE levels, whereas women experience a greater perceived disease burden, pruritus, psychiatric comorbidities, and more GI adverse events. These findings support the need to consider sex as a factor in the evaluation and comprehensive management of AD. © 2026 AEDV.

Datos de la publicación

ISSN/ISSNe:
0001-7310, 1578-2190

Actas Dermo-Sifiliograficas  ELSEVIER ESPANA

Tipo:
Article
Páginas:
-
PubMed:
42142841
Enlace a otro recurso:
www.scopus.com
Factor de Impacto:
0,279 SCImago ℠
Cuartil:
Q3 SCImago ℠

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Keywords

  • immunoglobulin E; interleukin 6; prasterone; sex hormone; testosterone; adolescent; adult; anxiety; Article; atopic dermatitis; biological therapy; blood level; child; comorbidity; controlled study; depression; Dermatology Life Quality Index; disease duration; disease severity; disease severity assessment; Eczema Area and Severity Index; eye disease; female; follow up; gastrointestinal discomfort; human; infection; infestation; major clinical study; male; Medical Dictionary for Regulatory Activities; neurologic disease; observational study; patient oriented eczema measure; prospective study; pruritus; quality of life; sex difference; skin disease; Spain; systemic therapy; treatment duration; vascular disease; visual analog scale

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