1. Inicio
  2. Publicaciones
  3. Prevalence and incidence of chronic kidney disease in patients with primary biliary cholangitis.

Prevalence and incidence of chronic kidney disease in patients with primary biliary cholangitis.

Fecha de publicación: Fecha Ahead of Print:

Autores de IIS La Fe

Participantes ajenos a IIS La Fe

  • Sousa JM
  • Rodríguez-Tajes S
  • Hernández-Guerra M
  • Casado M
  • Pérez-Castaño Y
  • Morillas R
  • Garcia-Retortillo M
  • García-Buey L
  • Simón MÁ
  • Gómez E
  • Jorquera F
  • Fernández-Rodríguez C
  • Hernández-Évole H
  • Ampuero J

Grupos

Abstract

BACKGROUND: Primary biliary cholangitis (PBC) is a liver disease frequently associated with extrahepatic manifestations. Although a relationship with kidney dysfunction has been reported, data about PBC and chronic kidney disease (CKD) are limited. We assessed the prevalence and incidence of CKD and identify associated risk factors in patients with PBC. METHODS: This was a multicenter retrospective study involving 1058 consecutive PBC patients. The presence of metabolic comorbidities, including diabetes, hypertension, and dyslipidemia was collected. CKD was defined as eGFR < 60 mL/min/1.73 m(2). RESULTS: Baseline CKD was found in 10% of patients. The number of metabolic factors was associated with progressively lower eGFR levels and higher rates of CKD. Hypertension[OR 2.77 (95%CI 1.60-4.82)], diabetes[OR 2.17(95%CI 1.13-4.18)], ALT[OR 0.92(95%CI 0.88-0.96)], albumin[OR 0.24(95%CI 0.13-0.43)], and platelets[OR 0.996(95%CI 0.992-0.999)] were associated with baseline CKD. CKD was associated with higher mortality (32.1% vs. 7.3%). Seven percent of patients developed CKD. Baseline FIB-4 was associated with CKD incidence: < 1.45: 3% (13/428), 1.45-3.25: 10.2% (31/303), > 3.25: 13.4% (11/82). Baseline eGFR values [OR 0.93(95%CI 0.90-0.96)], cirrhosis [OR 2.31(95%CI 1.09-4.88)], hypertension [OR 2.36 (95%CI 1.14-4.88)], and albumin [OR 0.31(95%CI 0.14-0.72)] were associated with CKD occurrence. Baseline eGFR values [OR 0.90 (95%CI 0.88-0.93)], hypertension at baseline [OR 2.01(95%CI 1.06-3.81)] and progression to cirrhosis [OR 4.50(95%CI 1.96-10.30)] were related to CKD incidence in non-cirrhotic patients. In the absence of comorbidities, maintaining treatment response after follow-up showed 0.9% of de novo CKD (vs. 8%). CONCLUSIONS: One of every ten PBC patients showed CKD, mainly related to metabolic factors (hypertension and diabetes), and advanced liver disease (albumin and platelets), increasing the risk of mortality. These conditions were also related to the CKD occurrence, even in non-cirrhotic patients.

© 2026. The Author(s), under exclusive licence to Japanese Society of Gastroenterology.

Datos de la publicación

ISSN/ISSNe:
0944-1174, 1435-5922

JOURNAL OF GASTROENTEROLOGY  SPRINGER JAPAN KK

Tipo:
Article
Páginas:
-
PubMed:
42329390

Documentos

  • No hay documentos

Métricas

Filiaciones mostrar / ocultar

Keywords

  • Chronic kidney disease; Glomerular filtration rate; Metabolic syndrome; Primary biliary cholangitis; Renal function

Cita

Compartir