Immunopathogenesis of invasive mould infections

Autores de IIS La Fe

• Miguel Salavert Lletí

  Autor

Participantes ajenos a IIS La Fe

• García-Vidal C

Grupos

• Infección Grave

Abstract

Invasive fungal infections caused by filamentous fungi are devastating diseases that occur in patients with a variety of immunosuppressive conditions. This review focuses on the pathogenesis of the most important invasive mycosis in the human being caused by the filamentous fungi Aspergillus, Fusarium, Scedosporium and mucorales. The first contact between the mould and the patient, the host defense to different fungi, including the role of mucosa in the innate immune system, the whole innate immune recognition receptors, and the pathways connecting innate and adaptive immunity, as well as the virulence factors of fungi, are discussed in this paper. (C) 2014 Revista Iberoamericana de Micologia. Published by Elsevier Espana, S.L.U. All rights reserved.

Keywords

• Aspergillus; Mucorales; Fusarium; Scedosporium; Toll-like receptors; Dectin-1; Pentraxin-3