Bronchopulmonary infection-colonization patterns in Spanish cystic fibrosis patients: Results from a national multicenter study

Autors de IIS La Fe

• Amparo Royuela Subiza

  Autor

• Amparo Solé Jover

  Autor

• Casilda Olveira Fuster

  Autor

• Elena Quintana Gallego

  Autor

Autors aliens a IIS La Fe

• de Dios Caballero J
• Del Campo R
• Máiz L
• de Gracia J
• Cobo M
• de la Pedrosa EG
• Oliver A
• Cantón R
• GEIFQ (Grupo Español para el Estudio de la Colonización/Infección Broncopulmonar

Grups d'Investigació

• Infección Grave

  

  Investigador Principal

  María Ángeles Tormo Mas

• Unidad Mixta de Investigacion en TICs aplicadas a la reingeniería en procesos sociosanitarios (ERPSS)

  Investigador Principal

  María Eugenia Gas López

Abstract

Background: Clinical and demographical knowledge on Spanish cystic fibrosis (CF) patients is incomplete as no national registry exists. CF-microbiology has not been studied at national level. The results of the first Spanish multicenter study on CF microbiology are presented. Methods: 24 CF-Units for adult (n = 12) and pediatric (n = 12) patients from 17 hospitals provided sputa and clinical data from 15 consecutive patients. Cultures and susceptibility testing were performed. Colonization impact on pulmonary function was assessed. Results: 341 patients [mean (SD) age 21 (11) years, 180 >= 18 years, mean (SD) FEV1 = 68 (25)%] were included. Pseudomonas aeruginosa was reported as chronic, intermittent or absent in 46%, 22% and 32% of patients, respectively. The annual prevalence was 62%. Positive P. aeruginosa and methicillin-resistant Staphylococcus aureus cultures were significantly associated with lower FEV1 (p < 0.001 and p = 0.003, respectively). Conclusions: The representative subset of the Spanish CF-population which has been clinically, demographically and microbiologically. characterized will serve as a reference for future CF studies in Spain. (C) 2015 European Cystic Fibrosis Society. Published by Elsevier B.V. All rights reserved.

Keywords

• Cystic fibrosis; Pulmonary infection-colonization; Respiratory pathogens; P. aeruginosa