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  3. microRNAs as epigenetic biomarkers for CTEPH: a case-control study towards personalised medicine.

microRNAs as epigenetic biomarkers for CTEPH: a case-control study towards personalised medicine.

Fecha de publicación: Fecha Ahead of Print:

Autores de IIS La Fe

Participantes ajenos a IIS La Fe

  • Tura-Ceide O
  • Hervás D
  • Sánchez-López V
  • Osorio J
  • Blanco I
  • Elias T
  • Jara-Palomares L
  • Gratacós-Aurich M
  • Barberà JA
  • Otero R

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Abstract

BACKGROUND: Chronic thromboembolic pulmonary hypertension (CTEPH) is a severe complication of acute pulmonary embolism (PE) in which delayed diagnosis significantly affects patient health outcomes. This case-control study aimed to identify a set of microRNAs (miRNAs) in plasma with diagnostic potential to differentiate patients with CTEPH from those with PE. METHODS: Two groups were analysed: 22 patients with confirmed CTEPH and 13 patients with PE, followed by validation in an independent cohort of 48 CTEPH and 37 PE patients. RESULTS: Using real-time PCR, eight miRNAs were identified as significantly different between the groups: miR-574-3p, miR-146b-5p, miR-193a-5p, miR-885-5p, miR-122-5p, miR-365a-3p, miR-142-3p and miR-192-5p. These miRNAs target key biological pathways, including vascular smooth muscle contraction, apoptosis and VEGF signalling, underlying the pathophysiology of CTEPH. The miRNA panel demonstrated strong diagnostic accuracy with an area under the curve of 0.843 in the validation cohort. CONCLUSIONS: The results highlight the potential of miRNA biomarkers as a diagnostic tool for early detection of CTEPH, representing a paradigm shift in its management, but further validation in larger cohorts is necessary to confirm their applicability. These insights could pave the way for improved clinical outcomes through timely diagnosis and targeted interventions.

Copyright ©The authors 2026.

Datos de la publicación

ISSN/ISSNe:
2312-0541, 2312-0541

ERJ Open Research  EUROPEAN RESPIRATORY SOC JOURNALS LTD

Tipo:
Article
Páginas:
-
PubMed:
41635579
Enlace a otro recurso:
www.scopus.com
Factor de Impacto:
0,944 SCImago ℠
Cuartil:
Q2 SCImago ℠

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Keywords

  • biological marker; epigenetic biomarker; microRNA; microRNA 122 5p; microRNA 142 3p; microRNA 146b 5p; microRNA 574 3p; microRNA 192 5p; microRNA 193a 5p; microRNA 365a 3p; microRNA 885 5p; small untranslated RNA; unclassified drug; adult; area under the curve; Article; bioinformatics; body mass; case control study; chronic thromboembolic pulmonary hypertension; cohort analysis; controlled study; diagnostic test accuracy study; differential gene expression; female; heart catheterization; high throughput sequencing; human; lung embolism; male; middle aged; muscle contraction; personalized medicine; polymerase chain reaction; predictive value; quality control; real time polymerase chain reaction; sensitivity and specificity; thromboembolism; vascular smooth muscle

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