Membranous glomerulonephritis and cellular crescents induced by levamisole-adulterated cocaine abuse: a case report.

Autores de IIS La Fe

• Lourdes Roca Argente

  Autor

• Jordi Espí Reig

  Autor

• Marino Blanes Juliá

  Autor

• Ana María García Martínez

  Autor

• Conrad Pujol Marco

  Autor

• Julio Hernández Jaras

  Autor

Participantes ajenos a IIS La Fe

• Moll-Guillen JL

Grupos

• Dermatología y Regeneración Tisular

• Farmacogenética

Abstract

Levamisole is illicitly employed as a cocaine adulterant. The consumption of levamisole-adulterated cocaine can provoke anti-neutrophil cytoplasmic antibody (ANCA)-associated syndromes. Patients carrying an HLAB27 allele are known to be at higher risk of developing agranulocytosis when treated with levamisole. Likewise, patients with ANCA-associated vasculitis (AAV) and internal organ involvement have typically been exposed to offending agents for prolonged periods of time, often on the order of years. Here, we report an unusual case of a patient in which kidney biopsy showed membranous glomerulonephritis with cellular crescents associated with levamisole-contaminated cocaine use.

Keywords

• Vasculitis; anti-neutrophil cytoplasmic antibody (ANCA); cocaine; glomerulonephritis; levamisole