'Herpes simplex virus infection in a bipulmonary transplant recipient'.

Autores de IIS La Fe

• Miguel Mansilla Polo

  Autor

• Daniel Martín Torregrosa

  Autor

• Javier López Davia

  Autor

Participantes ajenos a IIS La Fe

• Becerril-Andrés S

Grupos

• Dermatología y Regeneración Tisular

Abstract

This case reports a 45-year-old man with a history of bilateral lung transplantation for cystic fibrosis, on immunosuppressive therapy with tacrolimus and mycophenolate, presented with odynophagia. Examination showed painful ulcer clusters across the tongue, without oropharyngeal or systemic involvement. Labs and imaging were unremarkable. He had recently been hospitalized for pneumococcal pneumonia. PCR of vesicular fluid confirmed HSV-1 infection. Treatment with valacyclovir 500 mg twice daily for 7 days led to complete resolution, with no recurrence at 6 months. HSV may present atypically in immunocompromised patients; lingual involvement, though rare, should be considered in transplant recipients with clustered oral ulcers. © Springer-Verlag GmbH Germany, part of Springer Nature 2025.

Keywords

• C reactive protein; mycophenolate mofetil; mycophenolic acid; tacrolimus; valaciclovir; adult; antiviral therapy; Article; bilateral lung transplantation; blood cell count; case report; clinical article; clinical examination; clinical feature; controlled study; cystic fibrosis; diagnostic test; graft recipient; herpes simplex; high risk patient; hospital discharge; hospital patient; hospitalization; human; Human alphaherpesvirus 1; human tissue; immunocompromised patient; immunosuppressive treatment; kidney function test; laboratory test; liver function test; male; medical history; middle aged; mouth ulcer; odynophagia; physical examination; pneumococcal pneumonia; polymerase chain reaction; symptom; thorax radiography; tongue ulcer; treatment indication; vesicular fluid; article; diagnosis; drug therapy