Portal de investigación
Torque Teno Virus plasma DNA load: a novel prognostic biomarker in CAR-T therapy.
Autores de IIS La Fe
Participantes ajenos a IIS La Fe
- Benzaquén A
- Giménez E
- Iacoboni G
- Hernani R
- Albert E
- Carpio C
- Pérez A
- S de la Asunción C
- Sánchez-Salinas MA
- Piñana JL
- Beas F
- Hernández-Boluda JC
- Ferrer B
- Amat P
- Campos D
- Terol MJ
- Barba P
- Navarro D
- Solano C
Grupos
Abstract
Torque Teno Virus (TTV) is a single-stranded circular DNA virus which has been identified as a surrogate marker of immune competence in transplantation. In this study we investigated the dynamics of plasma TTV DNAemia in 79 adult patients undergoing chimeric antigen receptor T-cell (CAR-T) therapy for relapsed or refractory large B-cell lymphoma, also evaluating the impact of TTV on immunotoxicities, response and survival outcomes. After lymphodepleting therapy, TTV DNA load was found to decrease slightly until reaching nadir around day 10, after which it increased steadily until reaching maximum load around day 90. TTV DNA load < 4.05 log10 copies/ml at immune effector cell-associated neurotoxicity syndrome (ICANS) onset identified patients at risk of progressing to severe forms of ICANS (OR 16.68, P = 0.048). Finally, patients who experienced falling or stable TTV DNA load between lymphodepletion and CAR-T infusion had better progression-free survival than those with ascending TTV DNA load (HR 0.31, P = 0.006). These findings suggest that TTV monitoring could serve as a surrogate marker of immune competence, enabling predictions of CAR-T efficacy and toxicity. This could pave the way for the development of TTV-guided therapeutic strategies that modulate clinical patient management based on plasma TTV load, similar to suggested strategies in solid organ transplant recipients.
© 2023. The Author(s), under exclusive licence to Springer Nature Limited.
Datos de la publicación
- ISSN/ISSNe:
- 0268-3369, 1476-5365
- Tipo:
- Article
- Páginas:
- 93-100
- PubMed:
- 37919456
- Factor de Impacto:
- 0,998 SCImago ℠
- Cuartil:
- Q2 SCImago ℠
BONE MARROW TRANSPLANTATION SPRINGERNATURE
Citas Recibidas en Web of Science: 9
Documentos
- No hay documentos
Filiaciones
Cita
Benzaquén A,Giménez E,Iacoboni G,GUERREIRO M,Hernani R,Albert E,Carpio C,BALAGUER A,Pérez A,de la Asunción SC,Sánchez MA,CHORÃO P,Piñana JL,Beas F,MONTORO J,Hernández JC,FACAL A,Ferrer B,VILLALBA M,Amat P,GOMÉZ MD,Campos D,Terol MJ,SANZ J,Barba P,Navarro D,Solano C. Torque Teno Virus plasma DNA load: a novel prognostic biomarker in CAR-T therapy. Bone Marrow Transplant. 2024. 59. (1):p. 93-100. IF:5,200. (1).