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Biotechnological progresses in modelling the human endometrium: the evolution of current in vitro techniques and emerging trends.

Fecha de publicación: Fecha Ahead of Print:

Autores de IIS La Fe

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Abstract

The endometrium plays a fundamental role in the reproductive system yet many etiologies of infertility-related endometrial diseases such as endometriosis, adenomyosis, Asherman's syndrome or endometrial cancer remain unknown. There are currently no treatments that minimize the effects of this devastating disorder. Appropriate model systems that closely mimic the architecture and function of the endometrium in healthy and pathological states are needed to understand the underlying molecular pathways and develop novel or more effective treatments. This review summarizes the key milestones of in vitro culture models of the human endometrium throughout history, as well as the applications of advanced bioengineering techniques in the modelling of both healthy and pathological endometrium. Opportunities for future approaches are also discussed.

Copyright © 2024 Agustina-Hernández, Francés-Herrero, Gómez-Álvarez, Alonso-Frías, Romeu, Monzó, Ferrero, Bueno-Fernandez and Cervelló.

Datos de la publicación

ISSN/ISSNe:
2296-4185, 2296-4185

Frontiers in Bioengineering and Biotechnology  FRONTIERS MEDIA SA

Tipo:
Article
Páginas:
1495338-1495338
PubMed:
39698187
Factor de Impacto:
0,925 SCImago ℠
Cuartil:
Q1 SCImago ℠

Citas Recibidas en Web of Science: 4

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Keywords

  • cell culture; endometrial diseases; endometrial modelling; female reproduction; in vitro techniques; tissue engineering

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