Pediatric Liver and Kidney Transplant Recipients Demonstrate Greater Serological Response to SARS-CoV-2 Vaccination Than Adults.

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Autores de IIS La Fe

Participantes ajenos a IIS La Fe

  • Laue T
  • Ballester MP
  • Meoli L
  • Grabitz C
  • Uson E
  • D Antiga L
  • McLin V
  • Pujadas M
  • D'Amico F
  • Viganò R
  • Diago E
  • Lanseros BT
  • Inglese E
  • Vazquez DM
  • Broekhoven A
  • Kikkert M
  • Morales SPT
  • Myeni SK
  • Riveiro-Barciela M
  • Palom A
  • Zeni N
  • Brocca A
  • Cussigh A
  • Cmet S
  • Escudero-García MD
  • Stocco M
  • Natola LA
  • Ieluzzi D
  • Paon V
  • Sangiovanni A
  • Farina E
  • Dibenedetto C
  • Sánchez-Torrijos Y
  • Lucena-Varela A
  • Román E
  • Sánchez E
  • Sánchez-Aldehuelo R
  • López-Cardona J
  • Jeyanesan D
  • Morocho AE
  • Canas-Perez I
  • Eastgate C
  • Di Cola S
  • Lapenna L
  • Zaccherini G
  • Bongiovanni D
  • Riva A
  • Sharma R
  • Tsou HLP
  • Harris N
  • Zanaga P
  • Sayaf K
  • Hossain S
  • Crespo J
  • Robles-Díaz M
  • Madejón A
  • Degroote H
  • Korenjak M
  • Verhelst X
  • García-Samaniego J
  • Andrade RJ
  • Iruzubieta P
  • Wright G
  • Caraceni P
  • Merli M
  • Patel VC
  • Gander A
  • Albillos A
  • Soriano G
  • Donato MF
  • Sacerdoti D
  • Toniutto P
  • Buti M
  • Duvoux C
  • Grossi PA
  • Berg T
  • Polak WG
  • Puoti M
  • Bosch-Comas A
  • Belli LS
  • Burra P
  • Russo FP
  • Coenraad M
  • Calleja JL
  • Perricone G
  • Chokshi S
  • Clària J
  • Moreau R
  • Fernández J
  • Arroyo V
  • Angeli P
  • Sánchez-Garrido C
  • Ampuero J
  • Piano S
  • Nicastro E
  • Rock N
  • Shawcross D
  • Edwards L
  • Mutschler F
  • Melk A
  • Mehta G
  • Baumann U
  • Jalan R

Grupos

Abstract

BACKGROUND: Adult solid organ transplant recipients (SOTRs) have decreased responsiveness to severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2) vaccination and higher incidence of infection, but there are few data on the serological response in pediatric SOTR. The aim of this study was to determine serological response to SARS-CoV-2 vaccination in pediatric liver (LT) and kidney transplant (KT) recipients and compare it with adult SOTR. METHODS: A European, prospective, multicenter study was performed. Samples were taken at 7 and 32 wk following COVID-19 vaccination and serological endpoints were measured by ELISA. RESULTS: A total of 42 pediatric (16 post-LT and 26 post-KT) and 117 adult (all post-LT) were included. All pediatric participants and 94% adult participants received mRNA vaccines. Paediatric SOTR patients had significantly higher anti-Spike IgG levels than adult participants at week 7 (114 220.7 [59 285.92-220 058.55] versus 8756.7 [5643.69-13 586.71], P < 0.0001) and week 32 (46 113.2 [10 992.91-193 436.14] versus 8207.0 [3561.20-18 913.43], P = 0.0032). No significant difference in week 7 anti-Spike IgG response was found between pediatric LT and KT (129 434.4 [51 888.64-322 869.69] versus 105 304.5 [39 910.20-277 849.50], P = 0.9854). No differences were seen between children and adults in the rate of decline of anti-Spike IgG between weeks 7 and 32 (P = 0.8000). Male sex and hemolytic-uremic syndrome or postischemic kidney disease were associated with lower anti-Spike IgG levels at week 7 in pediatric SOTR. CONCLUSIONS: Paediatric SOTR demonstrate greater SARS-CoV-2 vaccine responses than comparable adult SOTR patients. These data support efficacy and safety of SARS-CoV-2 vaccination in child SOTR and may alleviate vaccine hesitancy in this patient group.

Copyright © 2025 The Author(s). Transplantation Direct. Published by Wolters Kluwer Health, Inc.

Datos de la publicación

ISSN/ISSNe:
2373-8731, 2373-8731

Transplantation Direct  LIPPINCOTT WILLIAMS & WILKINS

Tipo:
Article
Páginas:
1787-1787
PubMed:
40309027
Factor de Impacto:
0,728 SCImago
Cuartil:
Q2 SCImago

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Keywords

  • COVID-19 VACCINE; CHILDREN

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