Effect of low-dose vitamin D supplementation on uterine fibroid size in women with hypovitaminosis D: A nonrandomized pilot study.

Autores de IIS La Fe

• Alba Orive Boluda

  Autor

• Ana Corachán García

  Autor

• Julia Escrig Estrems

  Autor

• Javier Monleón Sancho

  Autor

• Hortensia Ferrero Chafer

  Autor

Participantes ajenos a IIS La Fe

• Mascarell-López MDM
• Pellicer A

Grupos

• Medicina Fetal y Reproductiva

Abstract

OBJECTIVE: To evaluate the effect of low-dose vitamin D supplementation on uterine fibroid (UF) size in patients with hypovitaminosis D. METHODS: This was a single-center observational study including a prospective interventional cohort and a retrospective comparative cohort. The control group (n = 16) included retrospective data from patients without vitamin D supplementation who attended two gynecological consultations 6 months apart. The interventional cohort (n = 15) prospectively received low-dose vitamin D supplementation (25 000 IU every 2 weeks for 6 months) and serum 25-hydroxyvitamin D levels, UF size and vascularization, and patients' symptoms and quality of life were evaluated at baseline and 3 and 6 months. RESULTS: In untreated controls, UFs grew significantly in 6 months (67.1 ± 20.2 mm versus 79.4 ± 29.7 mm, P < 0.001). Vitamin D supplementation significantly reduced UFs from 56.9 ± 14.5 mm at baseline to 53.3 ± 13.3 mm after 3 months (P = 0.03) and 52.2 ± 13.6 mm after 6 months (P = 0.001). UF vascularity index (5.5 ± 7.5%) and vascularization flow index (2.2 ± 3.4) was significantly lower at month 6 compared with baseline (7.6 ± 9.9% [P = 0.01] and 3.3 ± 5.4 [P = 0.009], respectively). CONCLUSION: Low-dose vitamin D supplementation effectively reduced UF size in women with hypovitaminosis D within 6 months, suggesting vitamin D is a promising solution for patients with UFs and hypovitaminosis D. CLINICAL TRIAL REGISTRATION: This study was registered on June 17, 2019, and the date of initial participant enrollment was July 9, 2019. NCT03991078, https://clinicaltrials.gov/study/NCT03991078.

© 2025 International Federation of Gynecology and Obstetrics.

Keywords

• cholecalciferol; hypovitaminosis; uterine fibroids; vitamin D