Influence of COX-inhibiting analgesics on the platelet function of patients with subarachnoid hemorrhage.

Autores de IIS La Fe

• Vera Parkhutik Matveeva

  Autor

• Aida Lago Martín

  Autor

• José Ignacio Tembl Ferrairo

  Autor

• María Paz Fuset Cabanes

  Autor

• Juana Valles Giner

  Autor

• Maria Teresa Santos Diaz

  Autor

• Antonio Moscardó Martínez

  Autor

Participantes ajenos a IIS La Fe

• Rubio C

Grupos

• Hemostasia, Trombosis, Arteriosclerosis y Biología vascular

Abstract

Platelet function of patients with subarachnoid hemorrhage (SAH) may play an important part in both rebleeding and delayed cerebral ischemia, but little is known about aggregation pathways during the acute phase of stroke. Analgesics are used regularly in the first days after bleeding, and some can potentially inhibit the cyclooxygenase (COX) enzyme. We examined the platelet function of patients with SAH in order to describe their basal situation and determine whether the administration of intravenous nonsteroidal antiinflammatory drugs (NSAIDs) affected platelet aggregation.