Lipid Oxidation at the Crossroads: Oxidative Stress and Neurodegeneration Explored in Caenorhabditis elegans

Data de publicació: 01/01/2025

Autors de IIS La Fe

Julia Tortajada Pérez

Autor
Andrea Del Valle Carranza Figuerca

Autor
Mar Collado Pérez

Autor
José María Millán Salvador

Autor
Gema García García

Autor

Autors aliens a IIS La Fe

Trujillo-del Rio, Cristina
Vazquez-Manrique, Rafael Pascual

Grups d'Investigació

Biomedicina Molecular, Celular y Genómica

Leader

José María Millán Salvador
Unidad mixta de investigación en enfermedades raras (CIPF)

Leader

José María Millán Salvador

Abstract

Lipid metabolism plays a critical role in maintaining cellular integrity, especially within the nervous system, where lipids support neuronal structure, function, and synaptic plasticity. However, this essential metabolic pathway is highly susceptible to oxidative stress, which can lead to lipid peroxidation, a damaging process induced by reactive oxygen species. Lipid peroxidation generates by-products that disrupt many cellular functions, with a strong impact on proteostasis. In this review, we explore the role of lipid oxidation in protein folding and its associated pathological implications, with a particular focus on findings in neurodegeneration from Caenorhabditis elegans studies, an animal model that remains underutilized. Additionally, we highlight the effectiveness of different methodologies applied in this nematode to deepen our understanding of this intricate process. In the nervous system of any animal, including mammals and invertebrates, lipid oxidation can disturb the delicate balance of cellular homeostasis, leading to oxidative stress, the build-up of toxic by-products, and protein misfolding, key factors in neurodegenerative diseases. This disruption contributes to the pathogenesis of neurodegenerative disorders such as Alzheimer's, Parkinson's, or Huntington's disease. The findings from Caenorhabditis elegans studies offer valuable insights into these complex processes and highlight potential avenues for developing targeted therapies to mitigate neurodegenerative disease progression.

Dades de la publicació

ISSN/ISSNe:: 2076-3921, 2076-3921
Tipus:: Review
Pàgines:: -
DOI:: 10.3390/antiox14010078
PubMed:: 39857412
Factor d'Impacte:: 1,008 SCImago ℠
Quartil:: Q1 SCImago ℠

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