Human Umbilical Cord-Based Therapeutics: Stem Cells and Blood Derivatives for Female Reproductive Medicine

Data de publicació: 01/12/2022

Autors de IIS La Fe

• Adolfo Rodríguez Eguren

  Autor

• María Gómez Álvarez

  Autor

• Emilio Francés Herrero

  Autor

• Mónica Romeu Villarroya

  Autor

• Hortensia Ferrero Chafer

  Autor

• Emre Seli

  Autor

• Irene Cervelló Alcaraz

  Autor

Grups d'Investigació

• Biología Reproductiva y Bioingeniería en Reproducción Humana

  

  Leader

  Nicolás Garrido Puchalt

• Endocrinología Reproductiva e Infertilidad

  Leader

  José Remohí Giménez

• Medicina Reproductiva

  

  Investigador Principal

  José Morales Roselló

Abstract

There are several conditions that lead to female infertility, where traditional or conventional treatments have limited efficacy. In these challenging scenarios, stem cell (SC) therapies have been investigated as alternative treatment strategies. Human umbilical cord (hUC) mesenchymal stem cells (hUC-MSC), along with their secreted paracrine factors, extracts, and biomolecules, have emerged as promising therapeutic alternatives in regenerative medicine, due to their remarkable potential to promote anti-inflammatory and regenerative processes more efficiently than other autologous treatments. Similarly, hUC blood derivatives, such as platelet-rich plasma (PRP), or isolated plasma elements, such as growth factors, have also demonstrated potential. This literature review aims to summarize the recent therapeutic advances based on hUC-MSCs, hUC blood, and/or other plasma derivatives (e.g., extracellular vesicles, hUC-PRP, and growth factors) in the context of female reproductive medicine. We present an in-depth analysis of the principal molecules mediating tissue regeneration, compiling the application of these therapies in preclinical and clinical studies, within the context of the human reproductive tract. Despite the recent advances in bioengineering strategies that sustain delivery and amplify the scope of the therapeutic benefits, further clinical trials are required prior to the wide implementation of these alternative therapies in reproductive medicine.

Keywords

• umbilical cord; female reproduction; umbilical cord mesenchymal stem cells; stem cell therapy; platelet-rich plasma; exosomes; growth factors; ovary; endometrium