Paradoxical effect of increased diastolic Ca(2+) release and decreased sinoatrial node activity in a mouse model of catecholaminergic polymorphic ventricular tachycardia.

Autores de IIS La Fe

• 

  Esther Zorio Grima

  Autor

Participantes ajenos a IIS La Fe

• Neco P
• Torrente AG
• Mesirca P
• Liu N
• Priori SG
• Napolitano C
• Richard S
• Benitah JP
• Mangoni ME
• Gómez AM

Grupos

• Hemostasia, Trombosis, Arteriosclerosis y Biología vascular

Abstract

Catecholaminergic polymorphic ventricular tachycardia is characterized by stress-triggered syncope and sudden death. Patients with catecholaminergic polymorphic ventricular tachycardia manifest sinoatrial node (SAN) dysfunction, the mechanisms of which remain unexplored.