Pregnancy and fertility in people with cystic fibrosis following lung transplantation.

Fecha de publicación: 01/11/2024 Fecha Ahead of Print: 27/08/2024

Autores de IIS La Fe

• Amparo Solé Jover

  Autor

Participantes ajenos a IIS La Fe

• Taylor-Cousar JL
• Jain R

Grupos

• Infección Grave

  

  Investigador Principal

  María Ángeles Tormo Mas

Abstract

PURPOSE OF REVIEW: The purpose of this review is to summarize available data on fertility, fertility preservation, pregnancy and parenthood following lung transplantation for people with cystic fibrosis (pwCF). RECENT FINDINGS: In the era of cystic fibrosis transmembrane conductance regulator (CFTR) modulator use, oral therapies that positively impact fundamental CFTR protein abnormalities, the number of pregnancies has increased dramatically with a concomitant decrease in lung transplantation. Nonetheless, some pwCF still require lung transplantation as a life-saving measure, and a fraction of those individuals desires parenthood. Cystic fibrosis (CF) providers infrequently discuss fertility preservation with pwCF, and pwCF feel uneducated about their fertility options posttransplant. However, because the immunosuppression required to successfully maintain lung allografts may impact future fertility, pwCF should receive genetic and reproductive counseling prior to lung transplantation. While pregnancies posttransplantation are high-risk, selected females with CF may be able to pursue this path to parenthood. SUMMARY: Although there is a paucity of data specific to pwCF who have undergone lung transplantation, recently developed general guidelines should inform discussions regarding fertility, pregnancy and parenthood in pwCF who desire parenthood following lung transplantation for optimal shared decision-making.

Copyright © 2024 The Author(s). Published by Wolters Kluwer Health, Inc.

Keywords

• cystic fibrosis; fertility; lung transplantation; parenthood; pregnancy