Metabolomics 2023 workshop report: moving toward consensus on best QA/QC practices in LC-MS-based untargeted metabolomics.

Fecha de publicación: 09/07/2024 Fecha Ahead of Print: 09/07/2024

Autores de IIS La Fe

• Julia Kuligowski

  Autor

Participantes ajenos a IIS La Fe

• Mosley, Jonathan D.
• Dunn, Warwick B.
• Lewis, Matthew R.
• Monge, Maria Eugenia
• Ulmer Holland, Candice
• Vuckovic, Dajana
• Zanetti, Krista A.
• Schock, Tracey B.
• Metabolomics Quality Assurance, Quality Control Consortium (mQACC)

Grupos

• Perinatología

  

  Leader

  Máximo Vento Torres

Abstract

INTRODUCTION: During the Metabolomics 2023 conference, the Metabolomics Quality Assurance and Quality Control Consortium (mQACC) presented a QA/QC workshop for LC-MS-based untargeted metabolomics. OBJECTIVES: The Best Practices Working Group disseminated recent findings from community forums and discussed aspects to include in a living guidance document. METHODS: Presentations focused on reference materials, data quality review, metabolite identification/annotation and quality assurance. RESULTS: Live polling results and follow-up discussions offered a broad international perspective on QA/QC practices. CONCLUSIONS: Community input gathered from this workshop series is being used to shape the living guidance document, a continually evolving QA/QC best practices resource for metabolomics researchers.

© 2024. This is a U.S. Government work and not under copyright protection in the US; foreign copyright protection may apply.

Keywords

• Data quality; Liquid chromatography–mass spectrometry (LC–MS); Metabolite annotation; Metabolite identification; Metabolomics; Quality assurance; Quality control (QC) samples; Reference materials