Portal de investigación
Risk factors for outcomes after unrelated cord blood transplantation for adults with acute lymphoblastic leukemia: a report on behalf of Eurocord and the Acute Leukemia Working Party of the European Group for Blood and Marrow Transplantation
Autores de IIS La Fe
Participantes ajenos a IIS La Fe
- Tucunduva L
- Ruggeri A
- Furst S
- Socié G
- Michallet M
- Arcese W
- Milpied N
- Yakoub-Agha I
- Linkesch W
- Cornelissen J
- Mannone L
- Iori AP
- Ribera JM
- Purtill D
- Labopin M
- Gluckman E
- Mohty M
- Rocha V
Grupos
Abstract
We performed a retrospective analysis on 421 adult patients who underwent unrelated cord blood transplantation (UCBT) for ALL. Median age was 32 years; 46% were in first CR (CR1), 32% in CR2 and 22% had advanced disease. Double UCBT was performed in 173 patients (41%). Myeloablative conditioning (MAC) was given to 314 patients (75%). Cumulative incidence (CI) of 60-day neutrophil recovery was 78%. CI of acute and chronic GVHD was 33 and 26%, respectively. Non-relapse mortality (NRM) at 2 years was 42%. Age >= 35 years (P < 0.0001), advanced disease at UCBT (P < 0.0001) and use of MAC (P < 0.0001) were associated with increased NRM. Relapse incidence (RI) at 2 years was 28%; use of reduced intensity conditioning (RIC) (P = 0.0002) was associated with increased RI. Two-year leukemia-free survival (LFS) was 39% for patients in CR1, 31% for CR2 and 8% for advanced disease. In multivariate analysis, factors associated with decreased LFS rate were: age >= 35 years (P = 0.034), use of MAC (P = 0.032) and advanced disease (P < 0.0001). These results show that UCBT is a valuable option to treat high-risk adult ALL when in remission. Strategies to decrease toxicity and relapse are needed to improve final outcomes.
Datos de la publicación
- ISSN/ISSNe:
- 0268-3369, 1476-5365
- Tipo:
- Article
- Páginas:
- 887-894
- DOI:
- 10.1038/bmt.2014.72
- PubMed:
- 24986801
- Factor de Impacto:
- 1,534 SCImago ℠
- Cuartil:
- Q1 SCImago ℠
BONE MARROW TRANSPLANTATION SPRINGERNATURE
Citas Recibidas en Web of Science: 15
Documentos
- No hay documentos
Filiaciones
Campos de Estudio
Cita
Tucunduva L,Ruggeri A,SANZ G,Furst S,Socié G,Michallet M,Arcese W,Milpied N,Yakoub I,Linkesch W,Cornelissen J,Mannone L,Iori AP,Ribera JM,SANZ J,MONTESINOS P,Purtill D,Labopin M,Gluckman E,Mohty M,Rocha V. Risk factors for outcomes after unrelated cord blood transplantation for adults with acute lymphoblastic leukemia: a report on behalf of Eurocord and the Acute Leukemia Working Party of the European Group for Blood and Marrow Transplantation. Bone Marrow Transplant. 2014. 49. (7):p. 887-894. IF:3,570. (2).