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  3. [Clinicopathological diagnosis of blastic plasmacytoid dendritic cell neoplasm: Report of three cases].

[Clinicopathological diagnosis of blastic plasmacytoid dendritic cell neoplasm: Report of three cases].

Fecha de publicación: Fecha Ahead of Print:

Autores de IIS La Fe

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Abstract

Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is a rare disease with a poor prognosis. It frequently affects the skin; indeed, dermal lesions may be the first clinical manifestation. We report three cases of BPDCN where the patients presented with skin lesions and describe the clinical, histopathological and immunohistochemical findings, its molecular characteristics and metastatic work-up. One of the patients remains in a clinical trial with IMGN632, a molecule directed against CD123, while the other two patients died after different therapeutic regimens. BPDCN is a complex diagnostic challenge which, together with its poor prognosis, requires close clinical-pathological cooperation in order to accelerate its diagnosis and offer early therapeutic alternatives with drugs directed against specific molecular targets.

Copyright © 2023 Sociedad Española de Anatomía Patológica. Publicado por Elsevier España, S.L.U. All rights reserved.

Datos de la publicación

ISSN/ISSNe:
1699-8855, 1988-561X

REVISTA ESPANOLA DE PATOLOGIA  Elsevier BV

Tipo:
Case Reports
Páginas:
53-58
PubMed:
38246711
Factor de Impacto:
0,158 SCImago ℠
Cuartil:
Q4 SCImago ℠

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Keywords

  • Blastic plasmacytoid dendritic cell neoplasm; CD123; Dermatopathology; Dermatopatología; IMGN632; Neoplasia de células dendríticas plasmocitoides blásticas

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