Portal de investigación
Impact of transplant eligibility and availability of a human leukocyte antigen-identical matched related donor on outcome of older patients with acute lymphoblastic leukemia
Autores de IIS La Fe
Participantes ajenos a IIS La Fe
- Barba P
- Martino R
- Olga G
- Esquirol A
- Gil-Cortés C
- Gonzalez J
- Fernandez-Avilés F
- Valcárcel D
- Guardia R
- Duarte RF
- Hernandez-Rivas JM
- Abella E
- Ribera JM
Grupos
Abstract
The role of allogeneic hematopoietic cell transplant (allo-HCT) in elderly patients with acute lymphoblastic leukemia (ALL) is unclear. We conducted a prospective study including 110 homogeneously treated patients with ALL aged 50-70 years. Their outcomes were analyzed by intention-to-treat on a donor-versus-no donor basis. Fifty-five patients (50%) underwent human leukocyte antigen (HLA) typing and were considered potential allo-HCT candidates, although only 25 (23%) eventually received an allo-HCT. Among potential allo-HCT candidates, patients with (n = 28) and without (n = 27) an HLA-identical sibling showed similar leukemia-free survival, overall survival (OS) and relapse risk, and the only variable associated with a better outcome was achievement of first complete remission (CR1) after induction therapy. Among the 25 patients who actually received an allo-HCT, the 4-year non-relapse mortality and OS were 42% (95% confidence interval 31-53%) and 37% (95% confidence interval 27-47%), respectively. In conclusion, having an HLA-identical sibling donor was not associated with a better outcome in patients with ALL aged 50-70 years.
Datos de la publicación
- ISSN/ISSNe:
- 1042-8194, 1029-2403
- Tipo:
- Article
- Páginas:
- 2812-2818
- PubMed:
- 25686647
- Factor de Impacto:
- 1,185 SCImago ℠
- Cuartil:
- Q2 SCImago ℠
Leukemia & lymphoma TAYLOR & FRANCIS LTD
Citas Recibidas en Web of Science: 4
Documentos
- No hay documentos
Filiaciones
Keywords
- Allogeneic transplant; acute lymphoblastic leukemia; RIC; HCT
Campos de Estudio
Cita
Barba P,Martino R,MARTINEZ D,Olga G,Esquirol A,Gil C,Gonzalez J,Fernandez F,Valcárcel D,Guardia R,Duarte RF,Hernandez JM,Abella E,MONTESINOS P,Ribera JM. Impact of transplant eligibility and availability of a human leukocyte antigen-identical matched related donor on outcome of older patients with acute lymphoblastic leukemia. Leuk Lymphoma. 2015. 56. (10):p. 2812-2818. IF:3,093. (2).