Repeated pancreatic resection for pancreatic metastases from renal cell Carcinoma: A Spanish multicenter study (PANMEKID).

Data de publicació: 27/01/2024 Data Ahead of Print: 27/01/2024

Autors de IIS La Fe

Rafael López Andújar

Autor

Autors aliens a IIS La Fe

Rojas-Holguin, Adela
Fondevila-Campo, Constantino
Sanjuanbenito, Alfonso
Fabregat-Prous, Joan
Secanella-Medayo, Luis
Rotellar-Sastre, Fernando
Pardo-Sanchez, Fernando
Prieto-Calvo, Mikel
Marin-Ortega, Hector
Sanchez-Cabus, Santiago
Diez-Valladares, Luis
Alonso-Casado, Oscar
Gonzalez-Serrano, Carmen
Rodriguez-Sanjuan, Juan Carlos
Garcia-Plaza, Gabriel
Jaen-Torrejimeno, Isabel
Suarez-Munoz, Miguel Angel
Becerra-Massare, Antonio
Rio, Paula Senra-del
Pando, Elizabeth
Munoz-Forner, Elena
Rodriguez-Lopez, Mario
Pereira, Fernando
Serrablo-Requejo, Alejandro
Turrion, Victor Sanchez
Garrido, Manuel Jimenez
Burdio, Fernando
Martin-Perez, Elena
Estevan-Estevan, Rafael
Lopez-Guerra, Diego
Castell-Gomez, Jose
Salinas-Gomez, Javier
Lopez-Baena, Jose Angel
Lopez-Ben, Santiago
Solar-Garcia, Lorena
Perez-Alonso, Alejandro J.
Martinez-Insfran, Luis Alberto
Blas, Juan Luis
Cornejo, Marian
Gutierrez-Calvo, Alberto
Pozo, Carlos Domingo -del
Ochando-Cerdan, Federico
Munoz-Bellvis, Luis
Rebollar-Saenz, Jose
Sanchez, Belinda
Jover, Jose Maria
Gomez-Bravo, Miguel Angel
Ramia, Jose M.
Blanco-Fernandez, Gerardo

Grups d'Investigació

Hepatología, Cirugia Hepatobiliopancreática y Trasplantes

Leader

Marina Berenguer Haym

Abstract

BACKGROUND AND OBJECTIVES: Recurrent isolated pancreatic metastasis from Renal Cell Carcinoma (RCC) after pancreatic resection is rare. The purpose of our study is to describe a series of cases of relapse of pancreatic metastasis from renal cancer in the pancreatic remnant and its surgical treatment with a repeated pancreatic resection, and to analyse the results of both overall and disease-free survival. METHODS: Multicenter retrospective study of patients undergoing pancreatic resection for RCC pancreatic metastases, from January 2010 to May 2020. Patients were grouped into two groups depending on whether they received a single pancreatic resection (SPS) or iterative pancreatic resection. Data on short and long-term outcome after pancreatic resection were collected. RESULTS: The study included 131 pancreatic resections performed in 116 patients. Thus, iterative pancreatic surgery (IPS) was performed in 15 patients. The mean length of time between the first pancreatic surgery and the second was 48.9 months (95% CI: 22.2-56.9). There were no differences in the rate of postoperative complications. The DFS rates at 1, 3 and 5 years were 86%, 78% and 78% vs 75%, 50% and 37% in the IPS and SPS group respectively (p=0.179). OS rates at 1, 3, 5 and 7 years were 100%, 100%, 100% and 75% in the IPS group vs 95%, 85%, 80% and 68% in the SPS group (p=0.895). CONCLUSION: Repeated pancreatic resection in case of relapse of pancreatic metastasis of RCC in the pancreatic remnant is justified, since it achieves OS results similar to those obtained after the first resection.