Increased doses of vaginal progesterone for the prevention of preterm birth in twin pregnancies: a randomised controlled double-blind multicentre trial.

Autores de IIS La Fe

• Vicente Serra Serra

  Autor

• Alfredo José Perales Marín

  Autor

• José Bellver Pradas

  Autor

• Juan Carlos Martinez Escoriza

  Autor

• Antonio Pellicer Martínez

  Autor

Participantes ajenos a IIS La Fe

• Meseguer J
• Parrilla JJ
• Lara C
• Grifol R
• Alcover I
• Sala M

Grupos

• Medicina Fetal y Reproductiva

Abstract

Previous trials have shown little benefit for preventing preterm birth in twin pregnancies using 90-200 mg of daily vaginal natural progesterone. Higher doses have not been tested. Our aim was to determine the efficacy and safety of two different daily doses of vaginal natural progesterone (200 and 400 mg), compared with placebo, for preventing preterm birth in unselected twin pregnancies.