Assessment of SARS-CoV-2 neutralizing antibody titers in breastmilk from convalescent and vaccinated mothers.

Autores de IIS La Fe

• Anna Parra Llorca

  Autor

Participantes ajenos a IIS La Fe

• Bauerl, Christine
• Zulaica, Joao
• Rusu, Luciana
• Moreno, Alicia Rodriguez
• Perez-Cano, Francisco J.
• Lerin, Carles
• Mena-Tudela, Desiree
• Aguilar-Camprubi, Laia
• Martinez-Costa, Cecilia
• Geller, Ron
• Collado, Maria Carmen
• MilkCORONA study team

Grupos

• Perinatología

  

  Leader

  Máximo Vento Torres

Abstract

Breastmilk contains antibodies that could protect breastfed infants from infections. In this work, we examined if antibodies in breastmilk could neutralize SARS-CoV-2 in 84 breastmilk samples from women that were either vaccinated (Comirnaty, mRNA-1273, or ChAdOx1), infected with SARS-CoV-2, or both infected and vaccinated. The neutralization capacity of these sera was tested using pseudotyped vesicular stomatitis virus carrying either the Wuhan-Hu-1, Delta, or BA.1 Omicron spike proteins. We found that natural infection resulted in higher neutralizing titers and that neutralization correlated positively with levels of immunoglobulin A in breastmilk. In addition, significant differences in the capacity to produce neutralizing antibodies were observed between both mRNA-based vaccines and the adenovirus-vectored ChAdOx1 COVID-19 vaccine. Overall, our results indicate that breastmilk from naturally infected women or those vaccinated with mRNA-based vaccines contains SARS-CoV-2 neutralizing antibodies that could potentially provide protection to breastfed infants from infection.

© 2023 The Author(s).

Keywords

• Health sciences; Immune response; Public health; Virology