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  3. Prognostic factors for satellitosis or in-transit metastasis in cutaneous squamous cell carcinoma: A multicentric cohort study.

Prognostic factors for satellitosis or in-transit metastasis in cutaneous squamous cell carcinoma: A multicentric cohort study.

Fecha de publicación: Fecha Ahead of Print:

Autores de IIS La Fe

Participantes ajenos a IIS La Fe

  • Marti-Marti I
  • Podlipnik S
  • Cañueto J
  • Ferrándiz-Pulido C
  • Deza G
  • Jaka A
  • Beà-Ardèbol S
  • Redondo P
  • Turrión-Merino L
  • Ruiz-Salas V
  • Masferrer E
  • Yébenes M
  • Sánchez-Schmidt JM
  • Gracia-Darder I
  • Altemir-Vidal A
  • Aguayo-Ortiz RS
  • Becerril S
  • Bodet-Castillo D
  • Leal L
  • Fuente MJ
  • Moreno-Arrones OM
  • Tomás-Velázquez A
  • Sandoval-Clavijo A
  • Toll A

Grupos

Abstract

BACKGROUND: Satellitosis or in-transit metastasis (S-ITM) has clinical outcomes comparable to node-positivity in cutaneous squamous cell carcinoma (cSCC). There is a need to stratify the risk groups. OBJECTIVE: To determine which prognostic factors of S-ITM confer an increased risk of relapse and cSCC-specific-death. METHODS: A retrospective, multicenter cohort study. Patients with cSCC developing S-ITM were included. Multivariate competing risk analysis evaluated which factors were associated with relapse and specific death. RESULTS: Of a total of 111 patients with cSCC and S-ITM, 86 patients were included for analysis. An S-ITM size of =20 mm, >5 S-ITM lesions, and a primary tumor deep invasion was associated with an increased cumulative incidence of relapse (subhazard ratio [SHR]: 2.89 [95% CI, 1.44-5.83; P = .003], 2.32 [95% CI, 1.13-4.77; P = .021], and 2.863 [95% CI, 1.25-6.55; P = .013]), respectively. Several >5 S-ITM lesions were also associated with an increased probability of specific death (SHR: 3.48 [95% CI, 1.18-10.2; P = .023]). LIMITATIONS: Retrospective study and heterogeneity of treatments. CONCLUSION: The size and the number of S-ITM lesions confer an increased risk of relapse and the number of S-ITM an increased risk of specific-death in patients with cSCC presenting with S-ITM. These results provide new prognostic information and can be considered in the staging guidelines.

Copyright © 2023 American Academy of Dermatology, Inc. Published by Elsevier Inc. All rights reserved.

Datos de la publicación

ISSN/ISSNe:
0190-9622, 1097-6787

JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY  MOSBY-ELSEVIER

Tipo:
Article
Páginas:
119-127
PubMed:
36907554
Enlace a otro recurso:
www.scopus.com
Factor de Impacto:
1,948 SCImago ℠
Cuartil:
Q1 SCImago ℠

Citas Recibidas en Web of Science: 6

Citas Recibidas en Scopus: 6

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Keywords

  • in-transit metastasis; satellite lesions; satellitosis; skin cancer; squamous cell carcinoma

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