What a difference two days make: "personalized" embryo transfer (pET) paradigm: A case report and pilot study

Autores de IIS La Fe

• Antonio Pellicer Martínez

  Autor

• Carlos Simon Valles

  Autor

Participantes ajenos a IIS La Fe

• Ruiz-Alonso M
• Galindo N

Grupos

• Medicina Reproductiva

  

  Investigador Principal

  José Morales Roselló

Abstract

Embryo implantation requires that the blastocyst will attach during the receptive stage of the endometrium, known as window of implantation (WOI). Historically, it has been assumed that the WOI is always constant in all women. However, molecular analyses of endometrial receptivity demonstrates a personalized WOI (pWOI) that is displaced in one out of four patients suffering from recurrent implantation failure (RIF) of endometrial origin and illustrates the utility of a personalized endometrial diagnostic approach. Here, we report a clinical case of successful personalized embryo transfer (pET) after four IVF and three oocyte donation failed attempts in which different embryo transfer strategies were attempted. This case report is complemented by a pilot study of 17 patients undergoing oocyte donation and who suffered failed implantations with routine embryo transfer (ET) but were then treated with pET after the personalized diagnosis of their WOI.

Keywords

• personalized embryo transfer; window of implantation; recurrent implantation failure; assisted reproduction