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Benefits and Harms of Conservative, Pharmacological, and Surgical Management Options for Women with Bladder Outlet Obstruction: A Systematic Review from the European Association of Urology Non-neurogenic Female LUTS Guidelines Panel

Benefits and Harms of Conservative, Pharmacological, and Surgical Management Options for Women with Bladder Outlet Obstruction: A Systematic Review from the European Association of Urology Non-neurogenic Female LUTS Guidelines Panel

Data de publicació: 01/09/2022

Autors de IIS La Fe

Salvador Arlandis Guzmán

Autor

Autors aliens a IIS La Fe

Peyronnet, Benoit
Lapitan, Marie Carmela
Tzelves, Lazaros
O'Connor, Eabhann
Riogh, Aisling Nic An
Manso, Margarida
Yuan, Cathy Yuhong
Bo, Kari
Costantini, Elisabetta
Farag, Fawzy
Groen, Jan
Nambiar, Arjun
Phe, Veronique
van der Vaart, Huub
Omar, Muhammad Imran
Harding, Chris

Grups d'Investigació

Urología

Leader

Francisco Boronat Tormo

Abstract

Context: While the management of bladder outlet obstruction (BOO) in men has been a topic of several systematic reviews and meta-analyses, no such evidence base exists for female BOO. Objective: The aim of this systematic review was to evaluate the benefits and harms of therapeutic interventions for the management of BOO in women. Evidence acquisition: This systematic review was conducted in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA) state-ment. The study protocol was registered with PROSPERO (CRD42020183839). A system-atic literature search was performed and updated by a research librarian in May 2021. The study population consisted of adult female patients diagnosed with BOO, who underwent treatment. Evidence synthesis: Out of 6344 records, we identified 33 studies enrolling 1222 partic-ipants, of which only six randomized controlled trials (RCTs) were found. One placebo -controlled crossover randomized trial assessed the role of baclofen in 60 female patients with dysfunctional voiding. The trial met its primary endpoint with a significantly greater decrease in the number of voids per day in the baclofen group (-5.53 vs - 2.70; p = 0.001). The adverse events were mild and comparable in both groups (25% vs 20%). One placebo-controlled crossover randomized trial assessed the role of sildenafil in 20 women with Fowler's syndrome. There were significant improvements from base-line in maximum urinary flow rate (Qmax), International Prostate Symptom Score (IPSS), and postvoid residual (PVR), but with no statistically significant difference when compared with placebo. In a large RCT including 197 female patients with functional BOO, the alpha-blocker alfuzosin significantly improved IPSS, Qmax, and PVR compared with baseline, but the differences were not statistically significant compared with the placebo group. Several small single-arm prospective series reported improvement of BOO-related symptoms and voiding parameters with urethroplasty, sling revision, ure-thral dilation, vaginal pessary, and pelvic organ prolapse repair. Conclusions: Evidence to support the use of conservative, pharmacological, and surgical treatments for BOO is scarce. Patient summary: According to the present systematic review of the literature, evidence to support the use of conservative, pharmacological, and surgical treatments for either anatomical or functional bladder outlet obstruction is scarce.(c) 2021 European Association of Urology. Published by Elsevier B.V. All rights reserved.