Portal de investigación
An enzyme-controlled mesoporous nanomachine for triple-responsive delivery
Autores de IIS La Fe
Participantes ajenos a IIS La Fe
- Mayol, Beatriz
- Dato, Victor
- Rodriguez, Manuel
- Lucena, Elena
- Villalonga, Anabel
- Diez, Paula
- Jimenez-Falcao, Sandra
- Sanchez, Alfredo
- Vilela, Diana
- Martinez-Ruiz, Paloma
- Villalonga, Reynaldo
Grupos
Abstract
The construction of a novel enzyme-controlled nanomachine with multiple release mechanisms for on-command delivery is described. This nanodevice was assembled by modifying mesoporous silica nanoparticles with 2-(benzo[d]thiazol-2-yl)phenyl 4-aminobenzoate moieties, and further capped with beta-cyclodextrin-modified glucose oxidase neoglycoenzyme. The device released the encapsulated payload in the presence of H2O2 and acidic media. The use of glucose as an input chemical signal also triggered cargo release through the enzymatic production of gluconic acid and hydrogen peroxide, and the subsequent disruption of the gating mechanism at the mesoporous surface. The nanodevice was successfully employed for the enzyme-controlled release of doxorubicin in HeLa cancer cells.
Datos de la publicación
- ISSN/ISSNe:
- 2050-750X, 2050-7518
- Tipo:
- Article
- Páginas:
- 6983-6990
- DOI:
- 10.1039/d2tb01069k
- PubMed:
- 36004753
- Factor de Impacto:
- 1,215 SCImago ℠
- Cuartil:
- Q1 SCImago ℠
Journal of Materials Chemistry B Royal Society of Chemistry
Citas Recibidas en Web of Science: 3
Documentos
- No hay documentos
Filiaciones
Keywords
- SILICA NANOPARTICLES; CANCER; RELEASE; DESIGN
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Cita
Mayol B,Dato V,Rodriguez M,Lucena E,Villalonga A,Diez P,Jimenez S,SANCENON F,Sanchez A,Vilela D,Martinez P,MARTINEZ R,Villalonga R. An enzyme-controlled mesoporous nanomachine for triple-responsive delivery. J Mater Chem B. 2022. 10. (36):p. 6983-6990. IF:7,000. (1).