COVID-19 mRNA vaccines have no effect on endometrial receptivity after euploid embryo transfer.

Fecha de publicación: 29/05/2022 Fecha Ahead of Print: 29/05/2022

Autores de IIS La Fe

Participantes ajenos a IIS La Fe

Brandao, Pedro

Grupos

Biología Reproductiva y Bioingeniería en Reproducción Humana

Leader

Nicolás Garrido Puchalt
Biomarcadores, Medicina Genómica, Estadística y Análisis masivo de datos en Reproducción humana asistida

Investigador Principal

Marcos Meseguer Escrivá
Endocrinología Reproductiva e Infertilidad

Leader

José Remohí Giménez
Medicina Reproductiva

Investigador Principal

José Morales Roselló

Abstract

RESEARCH QUESTION: Does the COVID-19 vaccination affect endometrial receptivity after single euploid embryo transfer, measured by sustained implantation rate? DESIGN: A retrospective cohort study analysing two groups of single euploid embryo transfers using own oocytes: one historical cohort of 3272 transfers 1 year before the pandemic; and one comprising 890 transfers in women previously vaccinated with mRNA vaccines against severe acute respiratory syndrome coronavirus 2. The main outcomes were clinical pregnancy rate (CPR) and sustained implantation rate (SIR) per embryo transfer. These outcomes were compared between non-vaccinated and vaccinated women, and women who had received one and two doses. Lastly, vaccinated women were divided into quartiles according to the time from last dose to embryo transfer. RESULTS: Similar CPR and SIR were found between non-vaccinated and vaccinated women, and the odds ratio for both outcomes was not statistically significant after being controlled for potential confounders (OR 0.937, 95% CI 0.695 to 1.265 and OR 0.910, 95% CI 0.648 to 1.227 respectively). Within the vaccinated group, women who had received one or two doses also had similar outcomes. In addition, no differences were found according to the time interval from vaccination to embryo transfer. CONCLUSION: The administration of mRNA vaccines against COVID-19 had no effect on endometrial receptivity and embryo implantation, regardless of the number of doses and time interval from vaccination to embryo transfer. The potential negative effect of the vaccine on endometrial receptivity and reproductive outcomes is reassuring for patients in the process of undergoing assisted reproductive treatment.

Datos de la publicación

ISSN/ISSNe:: 1472-6483, 1472-6491
Tipo:: Article
Páginas:: 688-695
DOI:: 10.1016/j.rbmo.2022.05.017
Factor de Impacto:: 1,171 SCImago ℠
Cuartil:: Q1 SCImago ℠

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Filiaciones

Brandao, Pedro:: IVIRMA Lisboa, Dept Reprod Med, H 1-9a,Ave Infante Dom Henrique 333, P-1800282 Lisbon, Portugal

Univ Porto, Fac Med, Alameda Prof Hernani Monteiro, P-4200319 Porto, Portugal
Pellicer, Antonio:: IVIRMA Roma, Dept Reprod Med, Largo Ildebrando Pizzetti 1,Piano 1 Interno 2, I-00197 Rome, Italy

Instituto de Investigación. IVI Fdn, Inst Invest Sanitaria La Fe, Ave Fernando Abril Martorell 106,Torre A, Valencia, Spain
Meseguer, Marcos:: Instituto de Investigación. IVI Fdn, Inst Invest Sanitaria La Fe, Ave Fernando Abril Martorell 106,Torre A, Valencia, Spain

IVIRMA Valencia, Dept Reprod Med, Plaza Policia Local 3, Valencia 46015, Spain
Remohi, Jose:: Instituto de Investigación. IVI Fdn, Inst Invest Sanitaria La Fe, Ave Fernando Abril Martorell 106,Torre A, Valencia, Spain

IVIRMA Valencia, Dept Reprod Med, Plaza Policia Local 3, Valencia 46015, Spain
Garrido, Nicolas:: Instituto de Investigación. IVI Fdn, Inst Invest Sanitaria La Fe, Ave Fernando Abril Martorell 106,Torre A, Valencia, Spain
Garcia-Velasco, Juan Antonio:: Instituto de Investigación. IVI Fdn, Inst Invest Sanitaria La Fe, Ave Fernando Abril Martorell 106,Torre A, Valencia, Spain

IVIRMA Madrid, Dept Reprod Med, Av Talgo 68, Madrid 28023, Spain

Univ Rey Juan Carlos, Mostoles Madrid 28933, Spain