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  3. Predictive Value of Immune Cell Functional Assay for Non-Cytomegalovirus Infection in Lung Transplant Recipients: A Multicenter Prospective Observational Study.

Predictive Value of Immune Cell Functional Assay for Non-Cytomegalovirus Infection in Lung Transplant Recipients: A Multicenter Prospective Observational Study.

Fecha de publicación:

Autores de IIS La Fe

Participantes ajenos a IIS La Fe

  • Monforte V
  • Ussetti P
  • Castejón R
  • Sintes H
  • Pérez VL
  • Laporta R
  • Cifrián JM
  • Marcos PJ
  • Redel J
  • Arcos IL
  • Berastegui C
  • Alonso R
  • Rosado S
  • Iturbe D
  • Ovalle JP
  • Vaquero JM
  • López-Meseguer M
  • Mendoza A
  • Gómez-Ollés S

Grupos

Abstract

INTRODUCTION: Immune cell functional assay (ImmuKnow®) is a non-invasive method that measures the state of cellular immunity in immunosuppressed patients. We studied the prognostic value of the assay for predicting non-cytomegalovirus (CMV) infections in lung transplant recipients. METHODS: A multicenter prospective observational study of 92 patients followed up from 6 to 12 months after transplantation was performed. Immune cell functional assay was carried out at 6, 8, 10, and 12 months. RESULTS: Twenty-three patients (25%) developed 29 non-CMV infections between 6 and 12 months post-transplant. At 6 months, the immune response was moderate (ATP 225-525ng/mL) in 14 (15.2%) patients and low (ATP<225ng/mL) in 78 (84.8%); no patients had a strong response (ATP=525ng/mL). Only 1 of 14 (7.1%) patients with a moderate response developed non-CMV infection in the following 6 months compared with 22 of 78 (28.2%) patients with low response, indicating sensitivity of 95.7%, specificity of 18.8%, positive predictive value (PPV) of 28.2%, and negative predictive value (NPV) of 92.9% (AUC 0.64; p=0.043). Similar acute rejection rates were recorded in patients with mean ATP=225 vs. <225ng/mL during the study period (7.1% vs. 9.1%, p=0.81). CONCLUSION: Although ImmuKnow® does not seem useful to predict non-CMV infection, it could identify patients with a very low risk and help us define a target for an optimal immunosuppression.

Datos de la publicación

ISSN/ISSNe:
0300-2896, 1579-2129

ARCHIVOS DE BRONCONEUMOLOGIA  ELSEVIER ESPANA SLU

Tipo:
Article
Páginas:
690-696
PubMed:
35699006
Factor de Impacto:
0,262 SCImago ℠
Cuartil:
Q3 SCImago ℠

Citas Recibidas en Web of Science: 2

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Keywords

  • Immuknow; Immune cell assay; Immunknow; Immunosuppression; Infección; Infection; Inmunosupresión; Lung transplant; Test de inmunidad celular; Trasplante pulmonar

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