Lung transplantation for acute respiratory distress syndrome - a retrospective European Cohort Study.

Fecha de publicación: 01/06/2022 Fecha Ahead of Print: 25/11/2021

Autores de IIS La Fe

Beatriz Montull Veiga

Autor

Participantes ajenos a IIS La Fe

Gottlieb, Jens
Lepper, Philipp M.
Berastegui, Cristina
Wald, Alexandra
Parmar, Jasvir
Magnusson, Jesper M.
Schönrath F
Laisaar, Tanel
Michel, Sebastian
Larsson, Hillevi
Vos, Robin
Haneya, Assad
Sandhaus, Tim
Verschuuren, Erik
le Pavec, Jerome
Tikkanen, Jussi
Hoetzenecker, Konrad

Grupos

Infecciones Respiratorias

Investigador Principal

Raúl Méndez Ocaña

Abstract

BACKGROUND: The published experience of lung transplantation (LTX) in acute respiratory distress syndrome (ARDS) is limited. The aim of this study was to investigate the contemporary results of LTX attempts in ARDS in major European centers. METHODS: We conducted a retrospective multicenter cohort study of all patients listed for LTX between 2011 and 2019. We surveyed 68 centers in 22 European countries. All patients admitted to the waitlist for lung transplantation with a diagnosis of "ARDS//pneumonia" were included. Patients without extracorporeal membrane oxygenation (ECMO) or mechanical ventilation were excluded. Patients were followed until October 1st 2020 or death. Multivariable analysis for 1-year survival after listing and lung transplantation were performed. RESULTS: Forty-eight centers (74%) with a total transplant activity of 12 438 lung transplants during the 9-year period gave feedback. Forty patients with a median age of 35 years were identified. Patients were listed for LTX in 18 different centers in 10 countries. Thirty-one-patients underwent LTX (0·25% of all indications) and 9 patients died on the waitlist. Ninety percent of transplanted patients were on ECMO in combination with mechanical ventilation before LTX. On multivariable analysis, transplantation during 2015 until 2019 was independently associated with better 1-year survival after LTX (odds ratio 10.493, 95% CI 1.977, 55.705, p=0.006). Sixteen survivors out of 23 patients with known status (70%) returned to work after LTX. CONCLUSION: LTX in highly selected ARDS patients is feasible and outcome has improved in the modern era. The selection process remains ethically and technically challenging.

Datos de la publicación

ISSN/ISSNe:: 0903-1936, 1399-3003
Tipo:: Article
Páginas:: -
DOI:: 10.1183/13993003.02078-2021
PubMed:: 34824051
Factor de Impacto:: 4,336 SCImago ℠
Cuartil:: Q1 SCImago ℠

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Métricas

Filiaciones

Gottlieb, Jens:: Biomedical Research in Endstage and Obstructive Lung Disease Hannover (BREATH), Member of the German Center for Lung Research (DZL), Hannover, Germany

Biomedical Research in Endstage and Obstructive Lung Disease Hannover (BREATH), Member of the German Center for Lung Research (DZL), Hannover, Germany
Lepper, Philipp M.:: Dept. of Internal Medicine V - Pneumology, Allergology and Critical Care Medicine, University Hospital of Saarland, and Saarland University, Homburg, Germany

Dept. of Internal Medicine V - Pneumology, Allergology and Critical Care Medicine, University Hospital of Saarland, and Saarland University, Homburg, Germany
Berastegui, Cristina:: Department of Respiratory Medicine, Lung Transplant Unit, Hospital Universitario Vall d'Hebron, Barcelona, Spain

Department of Respiratory Medicine, Lung Transplant Unit, Hospital Universitario Vall d'Hebron, Barcelona, Spain
Montull, Beatriz:: Department of Respiratory Medicine and Lung Transplant Unit, Hospital Universitario y Politécnico La Fe, Valencia, Spain

Department of Respiratory Medicine and Lung Transplant Unit, Hospital Universitario y Politécnico La Fe, Valencia, Spain
Wald, Alexandra:: Department of Pneumology, University Hospital Leipzig, Leipzig, Germany
Parmar, Jasvir:: Department of Respiratory Medicine, Royal Papworth Hospital, Cambridge Biomedical Campus, Cambridge, United Kingdom

Department of Respiratory Medicine, Royal Papworth Hospital, Cambridge Biomedical Campus, Cambridge, United Kingdom
Schönrath F:: Department of Cardiothoracic and Vascular Surgery, German Heart Center Berlin, Berlin, Germany

Department of Cardiothoracic and Vascular Surgery, German Heart Center Berlin, Berlin, Germany
Larsson, Hillevi:: Departement of Respiratory Medicine and Allergology, Skåne University Hospital, Lund, Sweden

Departement of Respiratory Medicine and Allergology, Skåne University Hospital, Lund, Sweden
Vos, Robin:: Department of Respiratory Diseases, University Hospitals Leuven - Campus Gasthuisberg, Leuven, Belgium

Laboratory of Respiratory Diseases and Thoracic Surgery (BREATHE), Department of Chronic Diseases and Metabolism, KU Leuven, Leuven, Belgium

Department of Respiratory Diseases, University Hospitals Leuven - Campus Gasthuisberg, Leuven, Belgium

Laboratory of Respiratory Diseases and Thoracic Surgery (BREATHE), Department of Chronic Diseases and Metabolism, KU Leuven, Leuven, Belgium
Haneya, Assad:: Department of Cardiac and Vascular Surgery, Campus Kiel, University-Medical-Center Schleswig-Holstein, Kiel, Germany

Department of Cardiac and Vascular Surgery, Campus Kiel, University-Medical-Center Schleswig-Holstein, Kiel, Germany
Sandhaus, Tim:: Department of Cardiovascular Surgery, University Hospital Jena, Jena, Germany
le Pavec, Jerome:: Service de Chirurgie Thoracique, Vasculaire et Transplantation Cardio-pulmonaire, Hôpital Marie-Lannelongue, Le Plessis-Robinson, France

Service de Chirurgie Thoracique, Vasculaire et Transplantation Cardio-pulmonaire, Hôpital Marie-Lannelongue, Le Plessis-Robinson, France
Tikkanen, Jussi:: Department of Pulmonary Medicine, Heart and Lung Center, Helsinki University Hospital and University of Helsinki, Helsinki, Finland

Department of Pulmonary Medicine, Heart and Lung Center, Helsinki University Hospital and University of Helsinki, Helsinki, Finland
Hoetzenecker, Konrad:: Department of Thoracic Surgery, Medical University of Vienna, Austria