Portal de investigación
Cytomegalovirus specific polyfunctional T-cell responses expressing CD107a predict control of CMV infection after liver transplantation.
Fecha de publicación:
Fecha Ahead of Print:
Autores de IIS La Fe
Participantes ajenos a IIS La Fe
- Corpas-Burgos F
- López-Labrador FX
Grupos
Abstract
Cytomegalovirus (CMV) viral load after liver transplantation (LT) is controlled by cell mediated immune responses (CMI). Quantification of CMV-specific T-cells may identify patients who control CMV spontaneously and avoid expensive and potentially toxic antiviral therapies. Prospective post-LT clinical, virological and immunological monitoring was carried out up to 1-year post-LT in a cohort of adult recipients. The CMV-specific T-cell response was characterized using flow cytometry intracellular cytokine staining in 49 LT recipients-R (79.6% R+, 20.4% R-). CMV infection occurred in 24 patients (18 D+/R+ and 6 D+/R-). Only patients with undetectable polyfunctional CMV-specific CD4+ T-cells developed CMV infection. Predictive models showed that polyfunctional CMV-specific CD4+ T-cells pre-existing before LT are protective for CMV reactivation posttransplantation. Quantitation of CD4+ T-cell responses to CMV may be a useful marker for spontaneous control of viral replication to tailor antiviral prophylaxis after LT.
Copyright © 2021 The Authors. Published by Elsevier Inc. All rights reserved.
Datos de la publicación
- ISSN/ISSNe:
- 0008-8749, 1090-2163
- Tipo:
- Article
- Páginas:
- 104455-104455
- PubMed:
- 34864514
- Factor de Impacto:
- 1,227 SCImago ℠
- Cuartil:
- Q2 SCImago ℠
CELLULAR IMMUNOLOGY ACADEMIC PRESS INC ELSEVIER SCIENCE
Citas Recibidas en Web of Science: 10
Documentos
- No hay documentos
Filiaciones
Keywords
- Cell mediated immune responses; Cytomegalovirus; Intracellular cytokine staining; Liver transplantation
Cita
CARVALHO Â,CUBELLS A,PALLARÉS C,Corpas F,BERENGUER M,AGUILERA V,López FX. Cytomegalovirus specific polyfunctional T-cell responses expressing CD107a predict control of CMV infection after liver transplantation. Cell Immunol. 2022. 371. p. 104455-104455. IF:4,300. (2).