Acute and sustained increase in endothelial biomarkers in COVID-19.

Autores de IIS La Fe

• Raúl Méndez Ocaña

  Autor

• Paula González Jiménez

  Autor

• Ana María Latorre Campos

  Autor

• Mónica Piqueras Rodríguez

  Autor

• Leyre Bouzas Yenes

  Autor

• Katheryn Yépez Borges

  Autor

• Ana Ferrando Cabida

  Autor

• Enrique Zaldivar Olmeda

  Autor

• Antonio Moscardó Martínez

  Autor

• Ricardo Miguel Alonso Díaz

  Autor

• Soledad Reyes Calzada

  Autor

• Rosario Menéndez Villanueva

  Autor

Grupos

• Hemostasia, Trombosis, Arteriosclerosis y Biología vascular

• Infecciones Respiratorias

Abstract

Endothelial injury is related to poor outcomes in respiratory infections yet little is known in relation to COVID-19. Performing a longitudinal analysis (on emergency department admission and post-hospitalisation follow-up), we evaluated endothelial damage via surrogate systemic endothelial biomarkers, that is, proadrenomedullin (proADM) and proendothelin, in patients with COVID-19. Higher proADM and/or proendothelin levels at baseline were associated with the most severe episodes and intensive care unit admission when compared with ward-admitted individuals and outpatients. Elevated levels of proADM or proendothelin at day 1 were associated with in-hospital mortality. High levels maintained after discharge were associated with reduced diffusing capacity.

© Author(s) (or their employer(s)) 2022. No commercial re-use. See rights and permissions. Published by BMJ.

Keywords

• COVID-19, pneumonia, respiratory infection, viral infection