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  3. Role of prenatal magnetic resonance imaging in fetuses with isolated anomalies of corpus callosum: multinational study

Role of prenatal magnetic resonance imaging in fetuses with isolated anomalies of corpus callosum: multinational study

Fecha de publicación:

Autores de IIS La Fe

Participantes ajenos a IIS La Fe

  • Sileo, Filomena Giulia
  • Pilu, Gianluigi
  • Prayer, Daniela
  • Rizzo, Giuseppe
  • Khalil, Asma
  • Managanaro, Lucia
  • Volpe, Paolo
  • Van Mieghem, Tim
  • Bertucci, Emma
  • Facchinetti, Fabio
  • Di Mascio, Daniele
  • Stampalija, Tamara
  • Buca, Danilo
  • Tinari, Sara
  • Oronzi, Ludovica
  • Ercolani, Giada
  • D'Amico, Alice
  • Matarrelli, Barbara
  • Cerra, Chiara
  • Fantasia, Ilaria
  • Pasquini, Lucia
  • Masini, Giulia
  • Olivieri, Claudiana
  • Ghi, Tullio
  • Frusca, Tiziana
  • Dall'Asta, Andrea
  • Visentin, Silvia
  • Cosmi, Erich
  • D'Errico, Ignazio
  • Villalain, Cecilia
  • Quintero, Olivia Mendez
  • Giancotti, Antonella
  • D'Ambrosio, Valentina
  • Antonelli, Amanda
  • Caulo, Massimo
  • Panara, Valentina
  • De Santis, Marco
  • Mappa, Ilenia
  • Prefumo, Federico
  • Pinelli, Lorenzo
  • Loscalzo, Gabriela
  • Bracalente, Gabriella
  • Liberati, Marco
  • Filippi, Elisa
  • Trincia, Elena
  • Pateisky, Petra
  • Kiss, Herbert
  • Curado, Joana
  • Almeida, Marta
  • Santos, Antonia
  • Galindo, Alberto
  • D'Antonio, Francesco
  • ENSO Working Grp

Grupos

Abstract

Objective To assess the performance of fetal magnetic resonance imaging (MRI) in detecting associated anomalies in fetuses diagnosed with isolated corpus callosal (CC) anomaly on multiplanar ultrasound evaluation of the fetal brain (neurosonography). Methods This was a multicenter, retrospective cohort study involving 14 fetal medicine centers in Italy, UK, Portugal, Canada, Austria and Spain. Inclusion criteria were fetuses with an apparently isolated CC anomaly, defined as an anomaly of the CC and no other additional central nervous system (CNS) or extra-CNS abnormality detected on expert ultrasound, including multiplanar neurosonography; normal karyotype; maternal age >= 18 years; and gestational age at diagnosis >= 18 weeks. The primary outcome was the rate of additional CNS abnormalities detected exclusively on fetal MRI within 2 weeks following neurosonography. The secondary outcomes were the rate of additional abnormalities according to the type of CC abnormality (complete (cACC) or partial (pACC) agenesis of the CC) and the rate of additional anomalies detected only on postnatal imaging or at postmortem examination. Results A total of 269 fetuses with a sonographic prenatal diagnosis of apparently isolated CC anomalies (207 with cACC and 62 with pACC) were included in the analysis. Additional structural anomalies of the CNS were detected exclusively on prenatal MRI in 11.2% (30/269) of cases, with malformations of cortical development representing the most common type of anomaly. When stratifying the analysis according to the type of CC anomaly, the rate of associated anomalies detected exclusively on MRI was 11.6% (24/207) in cACC cases and 9.7% (6/62) in pACC cases. On multivariate logistic regression analysis, only maternal body mass index was associated independently with the likelihood of detecting associated anomalies on MRI (odds ratio, 1.07 (95% CI, 1.01-1.14); P = 0.03). Associated anomalies were detected exclusively after delivery and were missed on both types of prenatal imaging in 3.9% (8/205) of fetuses with prenatal diagnosis of isolated anomaly of the CC. Conclusion In fetuses with isolated anomaly of the CC diagnosed on antenatal neurosonography, MRI can identify a small proportion of additional anomalies, mainly malformations of cortical development, which are not detected on ultrasound. (c) 2021 International Society of Ultrasound in Obstetrics and Gynecology.

Datos de la publicación

ISSN/ISSNe:
0960-7692, 1469-0705

ULTRASOUND IN OBSTETRICS & GYNECOLOGY  WILEY-BLACKWELL

Tipo:
Article
Páginas:
26-33
Factor de Impacto:
4,443 SCImago ℠
Cuartil:
Q1 SCImago ℠

Citas Recibidas en Web of Science: 23

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Keywords

  • central nervous system; corpus callosum; fetal magnetic resonance imaging; fetal ultrasound; MRI; neurosonography; prenatal diagnosis

Campos de estudio

Proyectos asociados

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Investigador Principal: MÁXIMO VENTO TORRES

RD12/0026/0012 . INSTITUTO DE SALUD CARLOS III; FUNDACIÓN PARA LA INVESTIGACIÓN DEL HOSPITAL UNIVERSITARIO LA FE DE LA COMUNIDAD VALENCIANA . 2013

PAPEL DEL FACTOR DE CRECIMIENTO PLACENTARIO EN EL MANEJO DE LA PREECLAMPSIA NO SEVERA: ESTUDIO ALEATORIZADO

Investigador Principal: ALFREDO JOSÉ PERALES MARÍN

PI15/01935 . INSTITUTO DE SALUD CARLOS III . 2016

Iplacenta. innovation in pacenta modelling for maternal and fetal health.

Investigador Principal: JOSÉ MORALES ROSELLÓ

765274 . COMISION EUROPEA . 2018

ENSAYO MULTICÉNTRICO, ABIERTO, ALEATORIZADO, DE DOSIS ÚNICA, CONTROLADO, DE XOMA 213 ADMINISTRADO POR VÍA INTRAVENOSA A MUJERES DESPUÉS DEL PARTO PARA LA SUPRESIÓN DE LA LACTANCIA.

Investigador Principal: ALFREDO JOSÉ PERALES MARÍN

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EVALUACIÓN DE LA EFICACIA DEL USO DE CLORHEXIDINA DURANTE EL PRIMER TRIMESTRE COMO REGULADOR DE LA MICROBIOTA VAGINAL EN LA REDUCCIÓN DE PARTO PREMATURO.

Investigador Principal: JOSÉ MORALES ROSELLÓ

PLUVA . 2021

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