Portal de investigación
Adverse prognostic impact of complex karyotype (>= 3 cytogenetic alterations) in adult T-cell acute lymphoblastic leukemia (T-ALL)
Fecha de publicación:
Fecha Ahead of Print:
Autores de IIS La Fe
Participantes ajenos a IIS La Fe
- Genesca, E
- Morgades, M
- Gonzalez-Gil, C
- Fuster-Tormo, F
- Haferlach, C
- Meggendorfer, M
- Barba, P
- Gil, C
- Coll, R
- Moreno, MJ
- Martinez-Carballeira, D
- Garcia-Cadenas, I
- Vives, S
- Ribera, J
- Gonzalez-Campos, J
- Diaz-Beya, M
- Mercadal, S
- Artola, MT
- Cladera, A
- Tormo, M
- Bermudez, A
- Vall-llovera, F
- Martinez-Sanchez, P
- Amigo, ML
- Monsalvo, S
- Novo, A
- Cervera, M
- Garcia-Guinon, A
- Ciudad, J
- Hernandez-Rivas, JM
- Granada, I
- Haferlach, T
- Orfao, A
- Sole, F
- Ribera, JM
Grupos
Abstract
The potential prognostic value of conventional karyotyping in adult T-cell acute lymphoblastic leukemia (T-ALL) remains an open question. We hypothesized that a modified cytogenetic classification, based on the number and type of cytogenetic abnormalities, would allow the identification of high-risk adult T-ALL patients. Complex karyotype defined by the presence of >3 cytogenetic alterations identified T-ALL patients with poor prognosis in this study. Karyotypes with >3 abnormalities accounted for 16 % (22/139) of all evaluable karyotypes, corre-sponding to the largest poor prognosis cytogenetic subgroup of T-ALL identified so far. Patients carrying kar-yotypes with >3 cytogenetic alterations showed a significantly inferior response to therapy, and a poor outcome in terms of event-free survival (EFS), overall survival (OS) and cumulative incidence of relapse (CIR), inde-pendently of other baseline characteristics and the end-induction minimal residual disease (MRD) level. Addi-tional molecular analyses of patients carrying >3 cytogenetic alterations showed a unique molecular profile that could contribute to understand the underlying molecular mechanisms of resistance and to evaluate novel tar-geted therapies (e.g. IL7R directed) with potential impact on outcome of adult T-ALL patients.
Datos de la publicación
- ISSN/ISSNe:
- 0145-2126, 1873-5835
- Tipo:
- Article
- Páginas:
- 106612-106612
- PubMed:
- 34139642
- Factor de Impacto:
- 0,865 SCImago ℠
- Cuartil:
- Q2 SCImago ℠
LEUKEMIA RESEARCH PERGAMON-ELSEVIER SCIENCE LTD
Citas Recibidas en Web of Science: 18
Documentos
- No hay documentos
Filiaciones
Keywords
- Prognosis; Cytogenetics; Adult T-ALL; NGS; Therapy
Campos de Estudio
Cita
Genesca E,Morgades M,Gonzalez C,Fuster F,Haferlach C,Meggendorfer M,MONTESINOS P,Barba P,Gil C,Coll R,Moreno MJ,Martinez D,Garcia I,Vives S,Ribera J,Gonzalez J,Diaz M,Mercadal S,Artola MT,Cladera A,Tormo M,Bermudez A,Vall F,Martinez P,Amigo ML,Monsalvo S,Novo A,Cervera M,Garcia A,Ciudad J,CERVERA J,Hernandez JM,Granada I,Haferlach T,Orfao A,Sole F,Ribera JM. Adverse prognostic impact of complex karyotype (>= 3 cytogenetic alterations) in adult T-cell acute lymphoblastic leukemia (T-ALL). Leuk. Res. 2021. 109. p. 106612-106612. IF:3,715. (3).