Portal de investigación
Comparison between Cerebroplacental Ratio and Umbilicocerebral Ratio in Predicting Adverse Perinatal Outcome in Pregnancies Complicated by Late Fetal Growth Restriction: A Multicenter, Retrospective Study
Autores de IIS La Fe
Participantes ajenos a IIS La Fe
- Di Mascio, D
- Herraiz, I
- Villalain, C
- Buca, D
- Sileo, FG
- Finarelli, A
- Bertucci, E
- Facchinetti, F
- Rizzo, G
- Brunelli, R
- Giancotti, A
- Muzii, L
- Maruotti, GM
- Carbone, L
- D'Amico, A
- Tinari, S
- Morelli, R
- Cerra, C
- Nappi, L
- Greco, P
- Liberati, M
- Galindo, A
- D'Antonio, F
Grupos
Abstract
Introduction: The role of cerebroplacental ratio (CPR) or umbilicocerebral ratio (UCR) to predict adverse intrapartum and perinatal outcomes in pregnancies complicated by late fetal growth restriction (FGR) remains controversial. Methods: This was a multicenter, retrospective cohort study involving 5 referral centers in Italy and Spain, including singleton pregnancies complicated by late FGR, as defined by Delphi consensus criteria, with a scan 1 week prior to delivery. The primary objective was to compare the diagnostic accuracy of the CPR and UCR for the prediction of a composite adverse outcome, defined as the presence of either an adverse intrapartum outcome (need for operative delivery/cesarean section for suspected fetal distress) or an adverse perinatal outcome (intrauterine death, Apgar score <7 at 5 min, arterial pH <7.1, base excess of >-11 mEq/mL, or neonatal intensive care unit admission). Results: Median CPR absolute values (1.11 vs. 1.22, p = 0.018) and centiles (3 vs. 4, p = 0.028) were lower in pregnancies with a composite adverse outcome than in those without it. Median UCR absolute values (0.89 vs. 0.82, p = 0.018) and centiles (97 vs. 96, p = 0.028) were higher. However, the area under the curve, 95% confidence interval for predicting the composite adverse outcome showed a poor predictive value: 0.580 (0.512-0.646) for the raw absolute values of CPR and UCR, and 0.575 (0.507-0.642) for CPR and UCR centiles adjusted for gestational age. The use of dichotomized values (CPR <1, UCR >1 or CPR <5th centile, UCR >95th centile) did not improve the diagnostic accuracy. Conclusion: The CPR and UCR measured in the week prior delivery are of low predictive value to assess adverse intrapartum and perinatal outcomes in pregnancies with late FGR.
Datos de la publicación
- ISSN/ISSNe:
- 1015-3837, 1421-9964
- Tipo:
- Article
- Páginas:
- 448-456
- DOI:
- 10.1159/000516443
- Factor de Impacto:
- 0,935 SCImago ℠
- Cuartil:
- Q1 SCImago ℠
FETAL DIAGNOSIS AND THERAPY KARGER
Citas Recibidas en Web of Science: 7
Documentos
- No hay documentos
Filiaciones
Keywords
- Cerebroplacental ratio; Umbilical artery; Perinatal outcome; Umbilicocerebral ratio
Financiación
Proyectos asociados
RED DE SALUD MATERNO INFANTIL Y DEL DESARROLLO
Investigador Principal: MÁXIMO VENTO TORRES
RD12/0026/0012 . INSTITUTO DE SALUD CARLOS III; FUNDACIÓN PARA LA INVESTIGACIÓN DEL HOSPITAL UNIVERSITARIO LA FE DE LA COMUNIDAD VALENCIANA . 2013
PAPEL DEL FACTOR DE CRECIMIENTO PLACENTARIO EN EL MANEJO DE LA PREECLAMPSIA NO SEVERA: ESTUDIO ALEATORIZADO
Investigador Principal: ALFREDO JOSÉ PERALES MARÍN
PI15/01935 . INSTITUTO DE SALUD CARLOS III . 2016
Iplacenta. innovation in pacenta modelling for maternal and fetal health.
Investigador Principal: JOSÉ MORALES ROSELLÓ
765274 . COMISION EUROPEA . 2018
Cita
Di D,Herraiz I,Villalain C,Buca D,Morales J,Loscalzo G,Sileo FG,Finarelli A,Bertucci E,Facchinetti F,Rizzo G,Brunelli R,Giancotti A,Muzii L,Maruotti GM,Carbone L,D'Amico A,Tinari S,Morelli R,Cerra C,Nappi L,Greco P,Liberati M,Galindo A,D'Antonio F. Comparison between Cerebroplacental Ratio and Umbilicocerebral Ratio in Predicting Adverse Perinatal Outcome in Pregnancies Complicated by Late Fetal Growth Restriction: A Multicenter, Retrospective Study. Fetal Diagn Ther. 2021. 48. (6):p. 448-456. IF:2,208. (4).