Machine Learning-Based Integration of Prognostic Magnetic Resonance Imaging Biomarkers for Myometrial Invasion Stratification in Endometrial Cancer

Autores de IIS La Fe

• Alejandro Rodríguez Ortega

  Autor

• Víctor Lago Leal

  Autor

• Amadeo Ten Esteve

  Autor

• Guillermina Montoliu Fornas

  Autor

• Santiago Domingo Del Pozo

  Autor

• Ángel Alberich Bayarri

  Autor

• 

  Luis Martí Bonmatí

  Autor

Participantes ajenos a IIS La Fe

• Alegre, A
• Carot-Sierra, JM

Grupos

• Investigacion Biomédica en Imagen (GIBI 2-30)

  Investigador Principal

  Leonor Cerdá Alberich

• Medicina Reproductiva

  

  Investigador Principal

  José Morales Roselló

Abstract

Background Estimation of the depth of myometrial invasion (MI) in endometrial cancer is pivotal in the preoperatively staging. Magnetic resonance (MR) reports suffer from human subjectivity. Multiparametric MR imaging radiomics and parameters may improve the diagnostic accuracy. Purpose To discriminate between patients with MI >= 50% using a machine learning-based model combining texture features and descriptors from preoperatively MR images. Study Type Retrospective. Population One hundred forty-three women with endometrial cancer were included. The series was split into training (n = 107, 46 with MI >= 50%) and test (n = 36, 16 with MI >= 50%) cohorts. Field Strength/Sequences Fast spin echo T2-weighted (T2W), diffusion-weighted (DW), and T1-weighted gradient echo dynamic contrast-enhanced (DCE) sequences were obtained at 1.5 or 3 T magnets. Assessment Tumors were manually segmented slice-by-slice. Texture metrics were calculated from T2W and ADC map images. Also, the apparent diffusion coefficient (ADC), wash-in slope, wash-out slope, initial area under the curve at 60 sec and at 90 sec, initial slope, time to peak and peak amplitude maps from DCE sequences were obtained as parameters. MR diagnostic models using single-sequence features and a combination of features and parameters from the three sequences were built to estimate MI using Adaboost methods. The pathological depth of MI was used as gold standard. Statistical Test Area under the receiver operating characteristic curve (AUROC), sensitivity, specificity, accuracy, positive predictive value, negative predictive value, precision and recall were computed to assess the Adaboost models performance. Results The diagnostic model based on the features and parameters combination showed the best performance to depict patient with MI >= 50% in the test cohort (accuracy = 86.1% and AUROC = 87.1%). The rest of diagnostic models showed a worse accuracy (accuracy = 41.67%-63.89% and AUROC = 41.43%-63.13%). Data Conclusion The model combining the texture features from T2W and ADC map images with the semi-quantitative parameters from DW and DCE series allow the preoperative estimation of myometrial invasion. Evidence Level 4 Technical Efficacy Stage 3

Keywords

• endometrial cancer; magnetic resonance; radiomics; diffusion; perfusion