Strategies for managing asherman's syndrome and endometrial atrophy: Since the classical experimental models to the new bioengineering approach

Data de publicació: 01/08/2021 Data Ahead of Print: 01/07/2021

Autors de IIS La Fe

• Lucia De Miguel Gómez

  Autor

• Mónica Romeu Villarroya

  Autor

• Irene Cervelló Alcaraz

  Autor

Autors aliens a IIS La Fe

• Pellicer A

Grups d'Investigació

• Biología Reproductiva y Bioingeniería en Reproducción Humana

  

  Leader

  Nicolás Garrido Puchalt

• Medicina Reproductiva

  

  Investigador Principal

  José Morales Roselló

Abstract

Endometrial function is essential for embryo implantation and pregnancy, but managing endometrial thickness that is too thin to support pregnancy or an endometrium of compromised functionality due to intrauterine adhesions is an ongoing challenge in reproductive medicine. Here, we review current and emerging therapeutic and experimental options for endometrial regeneration with a focus on animal models used to study solutions for Asherman's syndrome and endometrial atrophy, which both involve a damaged endometrium. A review of existing literature was performed that confirmed the lack of consensus on endometrial therapeutic options, though promising new alternatives have emerged in recent years (platelet-rich plasma, exosomes derived from stem cells, bioengineering-based techniques, endometrial organoids, among others). In the future, basic research using established experimental models of endometrial pathologies (combined with new high-tech solutions) and human clinical trials with large population sizes are needed to evaluate these emerging and new endometrial therapies.

Keywords

• bioengineering; endometrial regeneration; platelet-rich plasma; stem cells