Portal de investigación
Association of the thrombomodulin gene c.1418C>T polymorphism with thrombomodulin levels and with venous thrombosis risk.
Autores de IIS La Fe
Participantes ajenos a IIS La Fe
- Alberca I
- Roldán V
- Bertina RM
Grupos
Abstract
To investigate the association of the THBD c.1418C>T polymorphism, which encodes for the replacement of Ala455 by Val in thrombomodulin (TM), with venous thromboembolism (VTE), plasma soluble TM, and activated protein C levels. In addition, human umbilical vein endothelial cells (HUVEC) isolated from 100 umbilical cords were used to analyze the relation between this polymorphism and THBD mRNA and TM protein expression.
Datos de la publicación
- ISSN/ISSNe:
- 1079-5642, 1524-4636
- Tipo:
- Article
- Páginas:
- 1435-1440
- PubMed:
- 23520161
- Factor de Impacto:
- 3,072 SCImago ℠
- Cuartil:
- Q1 SCImago ℠
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY LIPPINCOTT WILLIAMS & WILKINS
Citas Recibidas en Web of Science: 32
Documentos
- No hay documentos
Filiaciones
Keywords
- endothelial cells, gene expression, protein C, thrombomodulin, venous thrombosis
Campos de Estudio
Cita
NAVARRO S,MEDINA P,BONET E,CORRAL J,MARTÍNEZ V,MARTOS L,RIVERA M,ROSELLÓ E,Alberca I,Roldán V,MIRA Y,FERRANDO F,ESTELLÉS A,VICENTE V,Bertina RM,ESPAÑA F. Association of the thrombomodulin gene c.1418C>T polymorphism with thrombomodulin levels and with venous thrombosis risk. Arterioscler. Thromb. Vasc. Biol. 2013. 33. (6):p. 1435-1440. IF:5,533. (1).