Stem cell secreted factor therapy regenerates the ovarian niche and rescues follicles.

Fecha de publicación: 01/07/2021 Fecha Ahead of Print: 01/02/2021

Autores de IIS La Fe

Ana Buigues Lafuente

Autor
Irene Cervelló Alcaraz

Autor
Antonio Pellicer Martínez

Autor
Sonia Herraiz Raya

Autor

Participantes ajenos a IIS La Fe

Marchante, Maria
De Miguel-Gomez, Lucia
Martinez, Jessica

Grupos

Biología Reproductiva y Bioingeniería en Reproducción Humana

Leader

Nicolás Garrido Puchalt
Medicina Reproductiva

Investigador Principal

José Morales Roselló

Abstract

Ovarian senescence is a normal age-associated phenomenon, but increasingly younger women are affected by diminished ovarian reserves or premature ovarian insufficiency. There is an urgent need for developing therapies to improve ovarian function in these patients. In this context, previous studies suggest that stem cell-secreted factors could have regenerative properties in ovaries.

Datos de la publicación

ISSN/ISSNe:: 0002-9378, 1097-6868
Tipo:: Article
Páginas:: -
DOI:: 10.1016/j.ajog.2021.01.023
Factor de Impacto:: 2,948 SCImago ℠
Cuartil:: Q1 SCImago ℠

Documentos

No hay documentos

Métricas

Filiaciones

Buigues, Anna:: IVI Foundation, 46026, Valencia, Spain

Reproductive Medicine Research Group

Instituto de Investigación. Biomedical Research Institute la Fe, 46026, Valencia, Spain

IVI Fdn, Valencia, Spain

Instituto de Investigación. Reprod Med Res Grp, Valencia, Spain

Instituto de Investigación. Inst Invest Sanitaria Fe IISLAFE, Valencia, Spain
Marchante, Maria:: IVI Foundation, 46026, Valencia, Spain

Department of Pediatrics, Obstetrics and Gynecology, School of Medicine, University of Valencia, 46010, Valencia, Spain

IVI Fdn, Valencia, Spain

Univ Valencia, Dept Pediat Obstet & Gynecol, Sch Med, Valencia, Spain
De Miguel-Gomez, Lucia:: IVI Foundation, 46026, Valencia, Spain

Department of Pediatrics, Obstetrics and Gynecology, School of Medicine, University of Valencia, 46010, Valencia, Spain

IVI Fdn, Valencia, Spain

Univ Valencia, Dept Pediat Obstet & Gynecol, Sch Med, Valencia, Spain
Martinez, Jessica:: IVI Foundation, 46026, Valencia, Spain

Department of Pediatrics, Obstetrics and Gynecology, School of Medicine, University of Valencia, 46010, Valencia, Spain

IVI Fdn, Valencia, Spain

Univ Valencia, Dept Pediat Obstet & Gynecol, Sch Med, Valencia, Spain
Cervello, Irene:: IVI Foundation, 46026, Valencia, Spain

Reproductive Medicine Research Group

Instituto de Investigación. Biomedical Research Institute la Fe, 46026, Valencia, Spain

IVI Fdn, Valencia, Spain

Instituto de Investigación. Reprod Med Res Grp, Valencia, Spain

Instituto de Investigación. Inst Invest Sanitaria Fe IISLAFE, Valencia, Spain
Pellicer, Antonio:: Reproductive Medicine Research Group

Instituto de Investigación. Biomedical Research Institute la Fe, 46026, Valencia, Spain

IVI-RMA Rome, 00197, Rome, Italy

Instituto de Investigación. Reprod Med Res Grp, Valencia, Spain

Instituto de Investigación. Inst Invest Sanitaria Fe IISLAFE, Valencia, Spain

IVI RMA Rome, Rome, Italy
Herraiz, Sonia:: IVI Foundation, 46026, Valencia, Spain

Reproductive Medicine Research Group

Instituto de Investigación. Biomedical Research Institute la Fe, 46026, Valencia, Spain

IVI Fdn, Valencia, Spain

Instituto de Investigación. Reprod Med Res Grp, Valencia, Spain

Instituto de Investigación. Inst Invest Sanitaria Fe IISLAFE, Valencia, Spain

Keywords

DNA repair, Ovarian rescue, diminished ovarian reserve, follicular growth, granulocyte colony stimulating factor mobilized plasma, ovarian niche regeneration, platelet activation, premature ovarian insufficiency, stem cell secreted factors, umbilical cord blood plasma