Myocardial G protein receptor-coupled kinase expression correlates with functional parameters and clinical severity in advanced heart failure.

Autores de IIS La Fe

• Jaume Agüero Ramón-Llin

  Autor

• Luis Almenar Bonet

  Autor

• Ignacio José Sánchez Lázaro

  Autor

• Diana Vicente Miralles

  Autor

• 

  Luis Vicente Martínez Dolz

  Autor

• Pilar D'ocon Navaza

  Autor

• Joaquín Rueda Soriano

  Autor

• Antonio Salvador Sanz

  Autor

Participantes ajenos a IIS La Fe

• Montó F
• Oliver E

Grupos

• Hemostasia, Trombosis, Arteriosclerosis y Biología vascular

Abstract

In heart failure (HF), sympathetic hyperactivation induces deleterious effects in myocardial ß-adrenergic signaling, with receptor down-regulation and desensitization mediated by G protein receptor-coupled kinases (GRKs). We hypothesised that changes in GRK isoforms may be associated with clinical status in advanced HF, using the Interagency Registry for Mechanically Assisted Circulatory Support (INTERMACS) scale.