Portal de investigación
New Metrics to Assess Type 2 Diabetes After Bariatric Surgery: The "Time-Within-Remission Range".
Fecha de publicación:
Fecha Ahead of Print:
Autores de IIS La Fe
Participantes ajenos a IIS La Fe
- Hollanda A
- Lecube A
- Rubio MA
- Sánchez E
- Vilarrasa N
- Oliva JG
- Fernández-Soto ML
- Salas-Salvadó J
- Ballesteros-Pomar MD
- Ciudin A
- Torres F
- Vidal C
- Morales MJ
- Valdés S
- Pellitero S
- Miñambres I
- Masmiquel L
- Goday A
- Suarez L
- Flores L
- Bueno M
- Caixàs A
- Bretón I
- Olbeyra R
- Penso R
- José de la Cruz M
- Simó-Servat A
- Pereyra-García FM
- López-Mezquita ET
- Gils A
- Fidilio E
- Bandrés O
- Martínez Á
- Abuín J
- Marques-Pamies M
- Tuneu L
- Arteaga M
- Castañer O
- Goñi F
- Arrizabalaga C
- Botana MA
- Calañas A
- Rebollo Á
Grupos
Abstract
Almost one third of patients do not achieve type 2 diabetes remission after bariatric surgery or are unable to sustain this effect long term. Our objective was to delve further into the dynamic responses of diabetes after bariatric surgery and to evaluate the "time-within-remission range" as a variable of metabolic control. A descriptive cohort study was done using a computerised multicentre and multidisciplinary registry. All data were adjusted by propensity score. A total of 1186 subjects with a follow-up of 4.5 ± 2.5 years were included. Type of surgery, diabetes remission, recurrence of diabetes, "time-within-remission range" and key predictors of diabetes outcomes were assessed. All patients (70% women, 51.4 ± 9.2 years old, body mass index (BMI) 46.3 ± 6.9 kg/m 2 ) underwent primary bariatric procedures. "Time-within-remission range" were 83.3% (33.3-91.6) after gastric bypass, 68.7% (7.1-87.5) after sleeve gastrectomy and 90% (83.3-92.8) after malabsorptive techniques ( p < 0.001 for all). Duration of diabetes, baseline HbA1c and insulin treatment were significantly negatively correlated with the "time-within-remission range". The association of bariatric techniques with "time-within-remission range", using gastric bypass as a reference, were: odds ratio (OR) 3.70 (2.34-5.84), p < 0.001 for malabsorptive techniques and OR 0.55 (0.40-0.75), p < 0.001 for sleeve gastrectomy. Characteristics of type 2 diabetes powerfully influence the outcomes of bariatric surgery. The "time-within-remission range" unveils a superiority of gastric bypass compared to sleeve gastrectomy.
Datos de la publicación
- ISSN/ISSNe:
- 2077-0383, 2077-0383
- Tipo:
- Article
- Páginas:
- -
- DOI:
- 10.3390/jcm9041070
Journal of clinical medicine MDPI AG
Citas Recibidas en Web of Science: 4
Documentos
- No hay documentos
Filiaciones
Keywords
- bariatric surgery, metabolic control, time-within-remission range, type 2 diabetes
Proyectos asociados
ESTUDIO FASE III, MULTICENTRICO, ALEATORIZADO, DOBLE CIEGO DE 48 SEMANAS, CON UN PERIDO INICIAL DE 12 SEMANAS CONTROLADO CON PLACEBO, PARA EVALUAR LA SEGURIDAD Y LA EFICACIA DE OSILODROSTAT EN PACIENTES CON ENFERMEDADES DE CUSHING.
Investigador Principal: ROSA CÁMARA GÓMEZ
CLCI699C2302 . 2016
ESTUDIO DE EXTENSIÓN, MULTICÉNTRICO, ABIERTO PARA EVALUAR LA SEGURIDAD A LARGO PLAZO EN PACIENTES CON SÍNDROME DE CUSHING ENDÓGENO QUE HAYAN COMPLETADO UN ESTUDIO ANTERIOR DE OSILODROSTAT (LCI699) PATROCINADO POR NOVARTIS Y QUE EL INVESTIGADOR CONSIDERE QUE SE ESTÁN BENEFICIANDO DEL TRATAMIENTO CONTINUADO CON OSILODROSTAT.
Investigador Principal: ROSA CÁMARA GÓMEZ
CLCI699C2X01B . 2018
ESTUDIO OBSERVACIONAL, TRASVERSAL Y MULTICÉNTRICO PARA VALORAR EL CUMPLIMENTO TERAPÉUTICO CON SOMAVERT® EN PACIENTES CON ACROMEGALIA EN CONDICIONES DE PRÁCTICA CLÍNICA HABITUAL.
Investigador Principal: ROSA CÁMARA GÓMEZ
PFI-PEG-2014-01 . 2015
ESTUDIO MUNDIAL SOBRE EL CONTROL Y LAS COMPLICACIONES DEL HIPOTITUITARISMO (HYPOCCS).
Investigador Principal: JUAN FRANCISCO MERINO TORRES
B9R-MC-GDGA . 2011
Cita
Hollanda A,Lecube A,Rubio MA,Sánchez E,Vilarrasa N,Oliva JG,Fernández ML,Salas J,Ballesteros MD,Ciudin A,Torres F,Vidal C,Morales MJ,Valdés S,Pellitero S,Miñambres I,Masmiquel L,Goday A,Suarez L,Flores L,Bueno M,Caixàs A,Bretón I,Cámara R,Olbeyra R,Penso R,José de la Cruz M,Simó A,Pereyra FM,López ET,Gils A,Fidilio E,Bandrés O,Martínez Á,Abuín J,Marques M,Tuneu L,Arteaga M,Castañer O,Goñi F,Arrizabalaga C,Botana MA,Calañas A,Rebollo Á. New Metrics to Assess Type 2 Diabetes After Bariatric Surgery: The "Time-Within-Remission Range". J Clin Med. 2020. 9. (4):1070. IF:4,241. (1).