1. Inicio
  2. Publicaciones
  3. Electro-responsive films containing voltage responsive gated mesoporous silica nanoparticles grafted onto PEDOT-based conducting polymer

Electro-responsive films containing voltage responsive gated mesoporous silica nanoparticles grafted onto PEDOT-based conducting polymer

Fecha de publicación: Fecha Ahead of Print:

Autores de IIS La Fe

Participantes ajenos a IIS La Fe

  • Lozano-Torres, B
  • Monreal-Trigo, J
  • Soto, J
  • Collazos-Castro, JE
  • Alcaniz, M

Grupos

Abstract

The characteristics and electromechanical properties of conductive polymers together to their biocompatibility have boosted their application as a suitable tool in regenerative medicine and tissue engineering. However, conducting polymers as drug release materials are far from being ideal. A possibility to overcome this drawback is to combine conducting polymers with on-command delivery particles with inherent high-loading capacity. In this scenario, we report here the preparation of conduction polymers containing gated mesoporous silica nanoparticles (MSN) loaded with a cargo that is delivered on command by electro-chemical stimuli increasing the potential use of conducting polymers as controlled delivery systems. MSNs are loaded with Rhodamine B (Rh B), anchored to the conductive polymer poly(3,4-ethylenedioxythiophene) (PEDOT) doped with poly[(4-styrenesulfonic acid)-co-(maleic acid)], functionalized with a bipyridinium derivative and pores are capped with heparin (P3) by electrostatic interactions. P3 releases the entrapped cargo after the application of -640?mV voltage versus the saturated calomel electrode (SCE). Pore opening in the nanoparticles and dye delivery is ascribed to both (i) the reduction of the grafted bipyridinium derivative and (ii) the polarization of the conducting polymer electrode to negative potentials that induce detachment of positively charged heparin from the surface of the nanoparticles. Biocompatibility and cargo release studies were carried out in HeLa cells cultures.

Datos de la publicación

ISSN/ISSNe:
0168-3659, 1873-4995

JOURNAL OF CONTROLLED RELEASE  Elsevier BV

Tipo:
Article
Páginas:
421-430
PubMed:
32371265
Factor de Impacto:
2,119 SCImago ℠
Cuartil:
Q1 SCImago ℠

Citas Recibidas en Web of Science: 14

Documentos

  • No hay documentos

Métricas

Filiaciones mostrar / ocultar

Keywords

  • Conducting polymers, Controlled release, Electro-responsive, PEDOT, Voltage-gated MSNs

Campos de Estudio

Proyectos y Estudios Clínicos

NANOMATERIALES INTELIGENTES, SONDAS Y DISPOSITIVOS PARA EL DESARROLLO INTEGRADO DE NUEVAS HERRAMIENTAS APLICADAS AL CAMPO BIOMÉDICO

Investigador Principal: JUAN BAUTISTA SALOM SANVALERO

MAT2015-64139-C4-1-R . MINISTERIO DE ECONOMIA Y COMPETITIVIDAD . 2016

PROGRAMA TÉCNICO DE APOYO. MODALIDAD INFRAESTRUCTURA.

Investigador Principal: RAMÓN MARTÍNEZ MÁÑEZ

PTA2016-12603-1 . MINISTERIO DE ECONOMIA Y COMPETITIVIDAD . 2018

Contrato I-PFIS: Predoctorales de formación en investigación en salud.

Investigador Principal: RAMÓN MARTÍNEZ MÁÑEZ

IFI17/00039 . INSTITUTO DE SALUD CARLOS III . 2018

Contrato Post FSE (Rio Hortega)

Investigador Principal: RAMÓN MARTÍNEZ MÁÑEZ

CM18/00078 . INSTITUTO DE SALUD CARLOS III . 2019

PLATAFORMA PARA LA DETECCIÓN DE PATÓGENOS BASADA EN MATERIALES CON PUERTAS MOLECULARES (PATH-GATE).

Investigador Principal: RAMÓN MARTÍNEZ MÁÑEZ

DTS18/00090 . INSTITUTO DE SALUD CARLOS III . 2019

Contrato i-PFIS Doctorados IIS - empresa en Ciencias y Tecnologías de la Salud.

Investigador Principal: FÉLIX SANCENÓN GALARZA

IFI19/00026 . INSTITUTO DE SALUD CARLOS III . 2020

Cita

Compartir