Initial experience of use of tolvaptan in critically ill patients with fluid overload

Autores de IIS La Fe

• Jesús Ruiz Ramos

  Autor

• Mónica Gordón Sahuquillo

  Autor

• Manuel Alejandro Cortés Herrera

  Autor

• María Jesús Broch Porcar

  Autor

• Paula Ramírez Galleymore

  Autor

Grupos

• Farmacogenética

• Infecciones Respiratorias

• Medicina Intensiva

Abstract

What is known and objective: Positive volume balance is related with high mortality in critically ill patients. We describe our experience in the use of tolvaptan in patients with fluid overload. Case summary: Six patients in the recovery phase from septic shock were included. All patients achieved an increase in diuresis after the first day, with a median fluid balance variation of -2362 (-485 to -3447) mL. At the end of treatment, median fluid balance variation was -9080 (-26 784 to -4395) mL. What is new and Conclusion: Tolvaptan could be an option in critically ill patients with fluid overload and resistant or not treatable with conventional diuretics.

Keywords

• clinical pharmacy; drug utilisation; furosemide