Portal de investigación
Association of SNPs with the efficacy and safety of immunosuppressant therapy after heart transplantation
Autores de IIS La Fe
Grupos
Abstract
Aim: Studying the possible influence of SNPs on efficacy and safety of calcineurin inhibitors upon heart transplantation. Materials & methods: In 60 heart transplant patients treated with tacrolimus or cyclosporine, we studied a panel of 36 SNPs correlated with a series of clinical parameters during the first post-transplantation year. Results: The presence of serious infections was correlated to ABCB1 rs1128503 (p = 0.012), CC genotype reduced the probability of infections being also associated with lower blood cyclosporine concentrations. Lower renal function levels were found in patients with rs9282564 AG (p = 0.003), related to higher blood cyclosporine blood levels. A tendency toward increased graft rejection (p = 0.05) was correlated to rs2066844 CC in NOD2/CARD15, a gene related to lymphocyte activation. Conclusion: Pharmacogenetics can help identify patients at increased risk of clinical complications. Original submitted 30 January 2015; revision submitted 27 March 2015
Datos de la publicación
- ISSN/ISSNe:
- 1462-2416, 1744-8042
- Tipo:
- Article
- Páginas:
- 971-979
- DOI:
- 10.2217/pgs.15.39
- PubMed:
- 26107754
- Factor de Impacto:
- 0,965 SCImago ℠
- Cuartil:
- Q2 SCImago ℠
PHARMACOGENOMICS TAYLOR & FRANCIS LTD
Citas Recibidas en Web of Science: 16
Documentos
- No hay documentos
Filiaciones
Keywords
- cyclosporine; graft rejection; infection; polymorphism; renal function; tacrolimus
Campos de Estudio
Cita
SÁNCHEZ I,HERRERO MJ,JORDÁN C,BOSÓ V,ALMENAR L,ROJAS L,MARTÍNEZ L,MEGÍAS JE,SENDRA L,MIGUEL A,POVEDA JL,ALIÑO SF. Association of SNPs with the efficacy and safety of immunosuppressant therapy after heart transplantation. Pharmacogenomics. 2015. 16. (9):p. 971-979. IF:2,710. (2).