Association of High Serum Levels of Growth Factors with Good Outcome in Ischemic Stroke: a Multicenter Study.

Fecha de publicación: 01/08/2020 Fecha Ahead of Print: 25/11/2019

Autores de IIS La Fe

• Antonio Davalos Errando

  Autor

• Raquel Serena Marti

  Autor

• Aida Lago Martín

  Autor

• Jéssica Castillo Villalba

  Autor

Participantes ajenos a IIS La Fe

• Sobrino T
• Rodríguez-Yáñez M
• Campos F
• Iglesias-Rey R
• Millán M
• de la Ossa NP
• Delgado-Mederos R
• Martínez-Domeño A
• Martí-Fábregas J
• Castellanos M
• Díez-Tejedor E

Grupos

• Hemostasia, Trombosis, Arteriosclerosis y Biología vascular

  

  Investigador Principal

  Pilar Medina Badenes

• Investigación en Neuroinmunología y Esclerosis Múltiple

  

  Leader

  Bonaventura Casanova Estruch

Abstract

The main objective of this research work was to study the association of serum levels of growth factors (GF) and SDF-1a with the functional outcome and reduction of lesion volume in ischemic stroke patients. In this multicenter study, 552 patients with non-lacunar stroke (male, 62.1%; mean age, 68.2 ± 11.4) were included within 24 h from symptom onset. The main outcome variable was good functional outcome (modified Rankin Scale [mRS] = 2) at 12 months. Secondary outcome variable was infarct volume (in mL) after 6 ± 3 months. Serum levels of VEGF, Ang-1, G-CSF, BDNF, and SDF-1a were measured by ELISA at admission, 7 ± 1 days, at 3 ± 1 months, and 12 ± 3 months. Except for BDNF, all GF and SDF-1a serum levels showed a peak value at day 7 and remained elevated during the first 3 months (all p < 0.01). High serum levels at day 7 of VEGF (OR, 19.3), Ang-1 (OR, 14.7), G-CSF (OR, 9.6), and SDF-1a (OR, 28.5) were independently associated with good outcome at 12 months (all p < 0.0001). On the other hand, serum levels of VEGF (B, - 21.4), G-CSF (B, - 14.0), Ang-1 (B, - 13.3), and SDF-1a (B, - 44.6) measured at day 7 were independently associated with lesion volume at 6 months (p < 0.01). In summary, high serum levels of VEGF, Ang-1, G-CSF, and SDF-1a at day 7 and 3 months after ischemic stroke are associated with good functional outcome and smaller residual lesion at 1 year of follow-up.

Keywords

• Growth factors, Infarct volume, Ischemic stroke, Prognosis