Review: Ewing Sarcoma Predisposition.

Autores de IIS La Fe

• Pablo Gargallo Tatay

  Autor

• Yania Yañez Peralta

  Autor

• Antonio Juan Ribelles

  Autor

• Vanessa Segura Caballer

  Autor

• Julia Balaguer Guill

  Autor

• Bárbara Torres Guerola

  Autor

• Juan Silvestre Oltra Soler

  Autor

• Victoria Castel Sánchez

  Autor

• Adela Cañete Nieto

  Autor

Grupos

• Investigación Clínica y Traslacional en Cáncer

• Investigación Traslacional en Genética

Abstract

Ewing sarcoma is a rare tumor developed in bone and soft tissues of children and teenagers. This entity is biologically led by a chromosomal translocation, typically including EWS and FLI1 genes. Little is known about Ewing sarcoma predisposition, although the role of environmental factors, ethnicity and certain polymorphisms on Ewing sarcoma susceptibility has been studied during the last few years. Its prevalence among cancer predisposition syndromes has also been thoroughly examined. This review summarizes the available evidence on predisposing factors involved in Ewing sarcoma susceptibility. On the basis of these data, an integrated approach of the most influential factors on Ewing sarcoma predisposition is proposed.

Keywords

• Cancer predisposition, Ewing sarcoma, Genetic susceptibility, Polymorphism