Hematopoietic stem cell transplantation with unrelated cord blood or haploidentical donor grafts in adult patients with secondary acute myeloid leukemia, a comparative study from Eurocord and the ALWP EBMT.

Data de publicació: 01/12/2019 Data Ahead of Print: 31/05/2019

Autors de IIS La Fe

Guillermo Sanz Santillana

Autor

Autors aliens a IIS La Fe

Ruggeri A
Labopin M
Savani B
Paviglianiti A
Blaise D
Volt F
Ciceri F
Bacigalupo A
Tischer J
Chevallier P
Koc Y
Cornelissen JJ
Ehninger G
Deconinck E
Rocha V
Baron F
Mohty M
Gluckman E
Nagler A

Grups d'Investigació

Hematología y Hemoterapia

Investigador Principal

Javier De La Rubia Comos

Abstract

Survival of patients with secondary acute myeloid leukemia (sAML) is poor. Cord blood transplantation (UCBT) and non-T-cell-depleted stem cell transplantation from haploidentical donors (HAPLO) are both strategies that have shown encouraging results in patients who do not have an human leukocyte antigen (HLA)-matched sibling or unrelated donor. We retrospectively analyzed outcomes of 409 adults with sAML receiving either UCBT (n = 163) or HAPLO (n = 246) in EBMT centers. Myelodysplastic syndrome (MDS) or myeloproliferative disorder (MPD) was the antecedent diagnosis in 79% of UCBT and 85% of HAPLO recipients. In multivariate analysis, UCBT was associated with higher risk of grade II-IV acute GVHD (HR 1.9, p = 0.009) and lower GHVD-free-relapse-free-survival (GRFS) (HR 1.57, p = 0.007) compared to HAPLO. Chronic-GVHD, RI, NRM, LFS, and OS were not statistically different between the two. Early disease stage at transplant was independently associated with lower RI and NRM and higher OS and LFS. These results indicate that HAPLO is associated with better GRFS and lower aGvHD compared to UCBT in patients with sAML and that UCBT can be a valid alternative for sAML patients who lack a matched sibling, a proper haploidentical or an unrelated donor.

Dades de la publicació

ISSN/ISSNe:: 0268-3369, 1476-5365
Tipus:: Article
Pàgines:: 1987-1994
DOI:: 10.1038/s41409-019-0582-5
PubMed:: 31150016
Factor d'Impacte:: 1,639 SCImago ℠
Quartil:: Q1 SCImago ℠

Documents

No hi ha documents

Mètriques

Filiacions

Ruggeri A:: Department of Pediatric Hematology and Oncology, IRCCS Bambino Gesù Children's Hospital, Piazza S.Onofrio, 4, Roma, 00165, Italy.
Labopin M:: Hôpital Saint Antoine, Service d'Hématologie et Thérapie Cellulaire, AP-HP, Paris, France
Savani B:: Vanderbilt University Medical Center, Nashville, TN, USA
Paviglianiti A:: Hôpital Saint Antoine, Service d'Hématologie et Thérapie Cellulaire, AP-HP, Paris, France
Blaise D:: Institut Paoli Calmettes, Marseille, France
Volt F:: Hôpital Saint Louis, Eurocord, IUH University Paris VII, Paris, France

Monacord, Centre Scientifique de Monaco, Monaco, Monaco
Ciceri F:: Hematology and BMT Unit, San Raffaele Scientific Institute, Milano, Italy
Bacigalupo A:: Hematology Department, Fondazione Policlinico Universitario Agostino Gemelli, Universita' Cattolica deI Sacro Cuore, Rome, Italy
Tischer J:: Ludwig Maximilian University Hospital of Munich, Munich, Germany
Chevallier P:: Service d'hématologie, Hôtel Dieu, Nantes, France
Koc Y:: Medical Park, Stem Cell Transplant Unit, Antalya, Turkey
Cornelissen JJ:: Erasmus MC Cancer Institute, University Medical Centre, Rotterdam, The Netherlands
Ehninger G:: Universitätsklinikum Carl Gustav Carus der TU Dresden, Medizinische Klinik und Poliklinik I, Dresden, Germany
Sanz G:: Hospital Universitario y Politécnico La Fe, Valencia, Spain

CIBERONC, Madrid, Spain
Deconinck E:: Hopital Jean Minjoz, Service d'Hématologie, Besançon, France
Rocha V:: Hôpital Saint Louis, Eurocord, IUH University Paris VII, Paris, France

Monacord, Centre Scientifique de Monaco, Monaco, Monaco
Baron F:: Department of Hematology, CHU of Liège, 4000, Liège, Belgium
Mohty M:: Hôpital Saint Antoine, Service d'Hématologie et Thérapie Cellulaire, AP-HP, Paris, France

INSERM, UMRs 938, Paris, France
Gluckman E:: Hôpital Saint Louis, Eurocord, IUH University Paris VII, Paris, France

Monacord, Centre Scientifique de Monaco, Monaco, Monaco
Nagler A:: Hôpital Saint Antoine, Service d'Hématologie et Thérapie Cellulaire, AP-HP, Paris, France

Chaim Sheba Medical Center, Tel-Hashomer, Israel