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  3. Integrative and comparative genomic analyses identify clinicallyrelevant pulmonary carcinoidgroups and unveil the supra-carcinoids.

Integrative and comparative genomic analyses identify clinicallyrelevant pulmonary carcinoidgroups and unveil the supra-carcinoids.

Fecha de publicación:

Autores de IIS La Fe

Participantes ajenos a IIS La Fe

  • Alcala N
  • Leblay N
  • Gabriel AAG
  • Mangiante L
  • Giffon T
  • Sertier AS
  • Ferrari A
  • Derks J
  • Ghantous A
  • Delhomme TM
  • Chabrier A
  • Cuenin C
  • Abedi-Ardekani B
  • Boland A
  • Olaso R
  • Meyer V
  • Altmuller J
  • Le Calvez-Kelm F
  • Durand G
  • Voegele C
  • Boyault S
  • Moonen L
  • Lemaitre N
  • Lorimier P
  • Toffart AC
  • Soltermann A
  • Clement JH
  • Saenger J
  • Field JK
  • Brevet M
  • Blanc-Fournier C
  • Galateau-Salle F
  • Le Stang N
  • Russell PA
  • Wright G
  • Sozzi G
  • Pastorino U
  • Lacomme S
  • Vignaud JM
  • Hofman V
  • Hofman P
  • Brustugun OT
  • Lund-Iversen M
  • Thomas de Montpreville V
  • Muscarella LA
  • Graziano P
  • Popper H
  • Stojsic J
  • Deleuze JF
  • Herceg Z
  • Viari A
  • Nuernberg P
  • Pelosi G
  • Dingemans AMC
  • Milione M
  • Roz L
  • Brcic L
  • Volante M
  • Papotti MG
  • Caux C
  • Hernandez-Vargas H
  • Brambilla E
  • Speel EJM
  • Girard N
  • Lantuejoul S
  • McKay JD
  • Foll M
  • Fernandez-Cuesta L

Grupos

Abstract

The worldwide incidence of pulmonary carcinoids is increasing, but little is known about their molecular characteristics. Through machine learning and multi-omics factor analysis, we compare and contrast the genomic profiles of 116 pulmonary carcinoids (including 35 atypical), 75 large-cell neuroendocrine carcinomas (LCNEC), and 66 small-cell lung cancers. Here we report that the integrative analyses on 257 lung neuroendocrine neoplasms stratify atypical carcinoids into two prognostic groups with a 10-year overall survival of 88% and 27%, respectively. We identify therapeutically relevant molecular groups of pulmonary carcinoids, suggesting DLL3 and the immune system as candidate therapeutic targets; we confirm the value of OTP expression levels for the prognosis and diagnosis of these diseases, and we unveil the group of supra-carcinoids. This group comprises samples with carcinoid-like morphology yet the molecular and clinical features of the deadly LCNEC, further supporting the previously proposed molecular link between the low- and high-grade lung neuroendocrine neoplasms.

Datos de la publicación

ISSN/ISSNe:
2041-1723, 2041-1723

Nature Communications  NATURE PORTFOLIO

Tipo:
Article
Páginas:
3407-3407
PubMed:
31431620
Factor de Impacto:
5,569 SCImago ℠
Cuartil:
Q1 SCImago ℠

Citas Recibidas en Web of Science: 168

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Keywords

  • CELL LUNG-CANCER; NEUROENDOCRINE TUMORS; DENDRITIC CELLS; EXPRESSION; CLASSIFICATION; MUTATIONS; DISCOVERY; PATHWAY; HEALTH; IDENTIFICATION

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