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LAUDES Study: impact of digital ulcers on hand functional limitation, work productivity and daily activities, in systemic sclerosis patients.

Fecha de publicación: Fecha Ahead of Print:

Autores de IIS La Fe

Participantes ajenos a IIS La Fe

  • Castellví I
  • Eguiluz S
  • Escudero-Contreras A
  • Ríos JJ
  • Calvo-Alén J
  • Callejas-Rubio JL
  • De la Puente C
  • Simeón CP
  • Narváez FJ
  • Espinosa G
  • Carreira PE
  • Rubio-Rivas M
  • Alegre JJ
  • Guillén-Del-Castillo A
  • Fonollosa V

Grupos

Abstract

The objective of this study was to evaluate the impact of digital ulcers (DUs) in daily life of systemic sclerosis (SSc) Spanish patients. We developed a multicenter observational study to compare functional disability in SSc patients with active DUs vs. those without DUs. An additional correlation between perception of patients and physicians on disability due to DUs was performed. A total of 199 patients were enrolled, 70 (35%) with DUs. Patients with DUs were younger (48 vs. 58years; p 0.001) and had more frequently the diffuse subtype of SSc (45 vs. 24%; p = 0.004) than patients without DUs. Patients with DUs showed significantly higher scores in the Cochin Hand Function Scale overall (p 0.002) and for each of its five dimensions. They also showed higher scores in the Systemic Sclerosis Health Assessment Questionnaire items related to hand function such as, dress and self-care (p 0.013), eat (p 0.013) and grip (p 0.03), and higher Visual Analogic Scale scores for pain (p 0.013), trouble related with Raynaud's Phenomenon (p 0.001) and sense of severity (p 0.004). Impact on daily activities was significantly higher in patients with DUs (p = 0.002), with a non-significant trend to experience higher impact on work productivity (p = 0.07). A high correlation was found between DUs patients and physicians opinion on the impact of DUs (daily life: Pearson R = 0.86; work productivity: Pearson R = 0.87). Study findings show an impaired hand function and increased disability for daily life activities and work productivity in SSc patients with DUs compared with patients without DUs in Spanish population.

Datos de la publicación

ISSN/ISSNe:
0172-8172, 1437-160X

RHEUMATOLOGY INTERNATIONAL  SPRINGER HEIDELBERG

Tipo:
Article
Páginas:
1875-1882
PubMed:
31522232
Factor de Impacto:
0,686 SCImago ℠
Cuartil:
Q2 SCImago ℠

Citas Recibidas en Web of Science: 22

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Keywords

  • Disability evaluation, Hand, Human activities, Quality of life, Scleroderma and related disorders

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